Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Electric Literature of 103-76-4.
Rasras, Anas J.;El-Naggar, Mohamed;Safwat, Nesreen A.;Al-Qawasmeh, Raed A. research published 《 Cholyl 1,3,4-oxadiazole hybrid compounds: design, synthesis and antimicrobial assessment》, the research content is summarized as follows. A new chem. library based on the hybridization of cholic acid with the heterocyclic moiety 1,3,4-oxadizoles I [R = 4-(phenyl)piperazin-1-yl, morpholino, benzyl(methyl)amino, etc.] were synthesized, and tested for antimicrobial activity against Gram-pos., Gram-neg. bacteria, and fungi. Among the synthesized compounds, the most potent derivatives against S. aureus were I [R = dibutylamino, 4-methylpiperazin-1-yl, pyrrolidin1-yl, 4-(2-fluorophenyl) piperazin-1-yl] with MIC values between 31 and 70μg/mL, while compound I [R = pyrrolidin1-yl] was the most active one against Bacillus subtilis with a MIC value of 70μg/mL. Interestingly, compounds I[R = 4-(phenyl)piperazin-1-yl, dihexylamino] exerted selective activity against Gram-pos. bacteria. The synthesized compounds I showed good activity against A. fumigatus and C. albicans and compound I [R = dicyclohexylamino] exhibited selective activity against fungi only.
Electric Literature of 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics