Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Safety of N-(2-Hydroxyethyl)piperazine.
Rani, Anu;Kumar, Sumit;Legac, Jenny;Adeniyi, Adebayo A.;Awolade, Paul;Singh, Parvesh;Rosenthal, Philip J.;Kumar, Vipan research published 《 Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials》, the research content is summarized as follows. WHO Malaria report 2017 estimated 216 million cases of malaria and 445,000 deaths worldwide, with 91% of deaths affecting the African region. Microwave promoted the synthesis of cycloalkyl amine substituted isoindoline-1,3-dione-4-aminoquinolines was urbanized for evaluating their antiplasmodial activities. Compound with the optimum combination of Pr chain length and hydroxyethyl piperazine proved to be the most potent among the synthesized scaffolds against chloroquine-resistant W2 strain of Plasmodium falciparum with an IC50 value of 0.006μM. Heme-binding along with d. functional theory studies were further carried out in order to delineate the mechanism of action of the most active compound The synthesized scaffold can act as a therapeutic template for further synthetic modifications toward the search for a new antimalarial agent.
Safety of N-(2-Hydroxyethyl)piperazine, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics