The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Electric Literature of 103-76-4.
Qi, Yinliang;Xu, Le;Li, Zhiwei;Gong, Ping;Hu, Tao;Yin, Bixi;Qin, Mingze;Liu, Yajing;Zhao, Yanfang;Hou, Yunlei research published 《 Design, synthesis and biological evaluation of novel pteridinone derivatives as potent dual inhibitors of PLK1 and BRD4》, the research content is summarized as follows. To develop novel simultaneous inhibition of PLK1 and BRD4 bromodomain by a single mol., three series of novel pteridinone derivatives I (X = N, CH; Z = N, CH, CMe; R1R2N = 4-methylpiperazin-1-yl, 3-methylpiperazin-1-yl, morpholin-4-yl, etc.) were designed, synthesized and evaluated for their biol. activity. Most of the synthesized compounds exhibited moderate to excellent cytotoxic activity against A549, HCT116, PC-3 and MCF-7 cell lines. The most promising compound I [X = N; Z = CMe; R1R2N = 4-cyclopentylpiperazin-1-yl; (II)] showed high antiproliferative effects on four cell lines with IC50 values of 1.27μM, 1.36μM, 3.85μM and 4.06μM, resp. The enzymic assay identified II as a potent PLK1 and BRD4 dual inhibitor with % inhibition values of 96.6 and 59.1, resp. Furthermore, to clarify the anticancer mechanism of the target compounds, explorations in the bioactivity were conducted. The results showed that compound II inhibited the proliferation of HCT-116 cell lines, induced a great decrease in the mitochondrial membrane potential leading to apoptosis of cancer cells, suppressed the migration of tumor cells and arrested the S phase of HCT116 cells.
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Electric Literature of 103-76-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics