The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Safety of N-(2-Hydroxyethyl)piperazine.
Lin, Wen-Hsing;Wu, Su-Ying;Yeh, Teng-Kuang;Chen, Chiung-Tong;Song, Jen-Shin;Shiao, Hui-Yi;Kuo, Ching-Chuan;Hsu, Tsu;Lu, Cheng-Tai;Wang, Pei-Chen;Wu, Tsung-Sheng;Peng, Yi-Hui;Lin, Hui-You;Chen, Ching-Ping;Weng, Ya-Ling;Kung, Fang-Chun;Wu, Mine-Hsine;Su, Yu-Chieh;Huang, Kuo-Wei;Chou, Ling-Hui;Hsueh, Ching-Cheng;Yen, Kuei-Jung;Kuo, Po-Chu;Huang, Chen-Lung;Chen, Li-Tzong;Shih, Chuan;Tsai, Hui-Jen;Jiaang, Weir-Torn research published 《 Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia》, the research content is summarized as follows. Gastrointestinal stromal tumors (GISTs) are prototypes of stem cell factor receptor (c-KIT)-driven cancer. Two receptor tyrosine kinases, c-KIT and fms-tyrosine kinase (FLT3), are frequently mutated in AML patients, and these mutations are associated with poor prognosis. In this study, the authors discovered a multitargeted tyrosine kinase inhibitor, (6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl)(5-pyridin-4-ylthiazol-2-yl)amine Hydrochloride [2581827-29-2] (15a), with potent inhibition against single or double mutations of c-KIT developed in GISTs. Moreover, crystal structure anal. revealed the unique binding mode of (15a) with c-KIT and may elucidate its high potency in inhibiting c-KIT kinase activity. (15A) inhibited cell proliferation and induced apoptosis by targeting c-KIT in c-KIT-mutant GIST cell lines. The antitumor effects of (15a) were also demonstrated in GIST430 and GIST patient-derived xenograft (PDX) models. Further studies demonstrated that (15a) inhibited the proliferation of c-KIT- and FLT3-driven AML cells in vitro and in vivo. The results of this study suggest that (15a) may be a potential anticancer drug for the treatment of GISTs and AML.
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Safety of N-(2-Hydroxyethyl)piperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics