The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Computed Properties of 103-76-4.
Li, Yongtao;Du, Renle;Nie, Yongwei;Wang, Tianqi;Ma, Yakun;Fan, Yan research published 《 Design, synthesis and biological assessment of novel CDK4 inhibitor with potent anticancer activity》, the research content is summarized as follows. In efforts toward finding potent CDK4 inhibitor for cancer therapy, a series of fluorine-substituted pyrrolo[2,3-d]pyrimidines I (R1, R2 = H, F; R = HO2C, 1-piperidinyl, 4-morpholinylcarbonyl, cyclopentylcarbamoyl, etc.) was designed, synthesized and evaluated. Among them, the optimal lead compound I [R1 = F; R2 = H; R = Me2NCH2CH2NHCO, (II)] was discovered with potent activity against CDK4 at the nanomolar level (IC50 = 2.5 nM) and exquisite selectivity which demonstrated only modest activity against 3 out of the 394 protein kinases. The compound II exhibited a much greater in vitro antiproliferative activity against several human cancer cell lines than that of the approved drug ribociclib. Further mechanism studies revealed that the compound II effectively stimulated cancer cell cycle arrest in G1 phase and induced tumor cell apoptosis. In the comparison of in vivo therapeutic effects in xenograft mouse models of breast cancer, oral administration of II showed a significantly better degree of inhibitory effect to ribociclib without obvious toxicity. All of the results indicated that the compound II could be a promising CDK4 inhibitor for treating malignancies.
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Computed Properties of 103-76-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics