Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. The -az- infix added to “piperazine” refers to the extra nitrogen atom, compared to piperidine. It is important to note, however, that piperazines are not derived from plants in the Piper genus. Electric Literature of 103-76-4.
Lei, Hongrui;Li, Zhen;Li, Tong;Wu, Huinan;Yang, Jing;Yang, Xinlian;Yang, Yu;Jiang, Nan;Zhai, Xin research published 《 Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model》, the research content is summarized as follows. Aiming to develop novel allosteric autotaxin (ATX) inhibitors, hybrid strategy was utilized by assembling the benzyl carbamate fragment in PF-8380 onto the imidazo[1,2-a]pyridines I (R = 3,5-dichlorophenyl, 2,3-dichlorophenyl, 4-(trifluoromethyl)phenyl, 2H-1,3-benzodioxol-5-yl, R1 = pyrrolidin-1-yl, morpholin-4-yl, 4-methylpiperazin-1-yl, etc.; R2 = Me, Et) skeleton of GLPG-1690. The piperazine moiety in GLPG-1690 was replaced with Ph ring to enhance the π-π interactions with adjacent residues. In the light of FS-3 based ATX enzymic assay, further structure-guided optimizations were implemented by exploring the substituents within the carbamate aromatic moiety and examining the effect of the 2-Et. Eventually, I (R = 2H-1,3-benzodioxol-5-yl; R1 = 4-(2-hydroxyethyl)piperazin-1-yl; R2 = Et) (II) bearing 1,3-benzodioxole and 2-hydroxyethyl piperazine group was identified as a powerful ATX inhibitor with an IC50 value of 2.7 nM. Subsequently, compound II was forwarded into an in vivo bleomycin-induced mice lung fibrosis model. In histopathol. and immunohistochem. assays, compound II could typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA. At a dose of 60 mg/kg, compound II was observed equivalent or even better potency than GLPG-1690 with a significant inhibition of the in vivo ATX activity. Except for the fundamental H-bond and π-π interactions, an extra H-bond between the 1,3-benzodioxole (O atom) and Phe306 offered great rationale in constraining the binding conformation of compound II. Finally, binding free energy calculation was conducted to assist in the efficient identification of allosteric ATX inhibitors.
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Electric Literature of 103-76-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics