The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Recommanded Product: N-(2-Hydroxyethyl)piperazine.
Kucukdumlu, Asligul;Tuncbilek, Meral;Guven, Ebru Bilget;Atalay, Rengul Cetin research published 《 Design, synthesis and in vitro cytotoxic activity of new 6,9-disubstituted purine analogues》, the research content is summarized as follows. A series of new 6,9-disubstituted purine analogs I [R = cyclohexyl, Ph, 4-CF3C6H4, etc., R1 = Cl, CF3] with 4-substituted piperazine at C-6 and 4-substituted benzyl at N-9 were designed and synthesized in four steps. All synthesized compounds I were screened initially for their in vitro anticancer activity on Huh7 liver, HCT116 colon and MCF7 breast carcinoma cell lines. Cytotoxic bioactivity studies revealed that all compounds I screened, with compound I [R = pyrimidine-2-yl, R1 = Cl] being the exception, were found to have promising cytotoxic activities at IC50 range of 0.05-21.8μM against cancer cells Huh7, HCT116 and MCF7. Among the prepared purine analogs, two of them (compounds I [R = 4-CF3C6H4, R1 = Cl, CF3]) exhibited excellent cytotoxic activities, with IC50 0.08-0.13μM, on Huh7 cells comparable to camptothecin (CPT) and better than cladribine, fludarabine and 5-FU. Afterwards, the evaluation of cytotoxicity of the most potent purine analogs was screened against further hepatocellular cancer (HCC) cell lines. The compounds I [R = 4-CF3C6H4, R1 = CF3; R = 3,4-Cl2C6H3, R1 = Cl] displayed a significant IC50 values (IC50 < 0.1-0.13μM) comparable to CPT and better cytotoxic bioactivity when compared with 5-FU, cladribine and fludarabine on HCC cells (Huh7 and HepG2).
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Recommanded Product: N-(2-Hydroxyethyl)piperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics