Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Name: N-(2-Hydroxyethyl)piperazine.
Shalini;Kumar, Sumit;Gendrot, Mathieu;Fonta, Isabelle;Mosnier, Joel;Cele, Nosipho;Awolade, Paul;Singh, Parvesh;Pradines, Bruno;Kumar, Vipan research published 《 Amide Tethered 4-Aminoquinoline-naphthalimide Hybrids: A New Class of Possible Dual Function Antiplasmodials》, the research content is summarized as follows. A series of amide tethered 4-aminoquinoline-naphthalimide hybrids I (R = H, Br; n = 2, 3, 6, etc.) and II (n = 2, 3, 4, etc.; -R1R2– = -(CH2)5-, -(CH2)2O(CH2)2-, -(CH2)2N(CH2)2OH(CH2)2-) has been synthesized to assess their in vitro antiplasmodial potential against chloroquine-susceptible (3D7) and chloroquine-resistant (W2) strains of Plasmodium falciparum. The most active and noncytotoxic compound had an IC50 value of 0.07μM against W2 strain and was more active than standard antimalarial drugs, including chloroquine, desethylamodiaquine, and quinine, particularly for drug resistant malaria. The promising scaffold, when subjected to heme binding and mol. modeling studies, was identified as a possible potent inhibitor of hemozoin formation and P. falciparum chloroquine resistance transporter (PfCRT), resp., and, therefore, could act as a dual function antiplasmodial.
Name: N-(2-Hydroxyethyl)piperazine, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics