The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. HPLC of Formula: 103-76-4.
Cao, Meng;Chen, Yuxiang;Zhao, Tianming;Wei, Shangfei;Guo, Ming;Zhai, Xin research published 《 Pyrroformyl-containing 2,4-diaminopyrimidine derivatives as a new optimization strategy of ALK inhibitors combating mutations》, the research content is summarized as follows. Aiming to identify new optimization strategy effective for ALK-mutations, two series of pyrroformyl-containing 2,4-diaminopyrimidine compounds I [R1 = methylsulfonylamino, N-methylcarbamoyl; R2 = -MeO, -OH, 1-piperidyl] were designed, synthesized and evaluated for their anti-proliferative activities against three cancer cell lines in-vitro by MTT assay. The biol. evaluations on cellular assay resulted in discovery of compound I [R1 = methylsulfonylamino; R2 = hydroxyethylamino] which performed considerable activity with IC50 value of 0.034μM against H2228 cell. Meanwhile, I [R1 = methylsulfonylamino; R2 = hydroxyethylamino] exhibited outstanding enzymic inhibitory potency with IC50 values of 1.9 nM and 3.1 nM against ALKWT and ALKL1196M, resp., surpassing the reference ceritinib (IC50 = 2.4 nM and 7.6 nM). Ultimately, the binding mode of I [R1 = methylsulfonylamino; R2 = hydroxyethylamino] with ALK was established to explore the SARs. Overall, I [R1 = methylsulfonylamino; R2 = hydroxyethylamino] was considered as a promising ALK inhibitor for mutation treatment.
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, HPLC of Formula: 103-76-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics