The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Reference of 103-76-4.
Bolaender, Alexander;Zatorska, Danuta;He, Huazhong;Joshi, Suhasini;Sharma, Sahil;Digwal, Chander S.;Patel, Hardik J.;Sun, Weilin;Imber, Brandon S.;Ochiana, Stefan O.;Patel, Maulik R.;Shrestha, Liza;Shah, Smit. K.;Wang, Shuo;Karimov, Rashad;Tao, Hui;Patel, Pallav D.;Martin, Ananda Rodilla;Yan, Pengrong;Panchal, Palak;Almodovar, Justina;Corben, Adriana;Rimner, Andreas;Ginsberg, Stephen D.;Lyashchenko, Serge;Burnazi, Eva;Ku, Anson;Kalidindi, Teja;Lee, Sang Gyu;Grkovski, Milan;Beattie, Bradley J.;Zanzonico, Pat;Lewis, Jason S.;Larson, Steve;Rodina, Anna;Pillarsetty, Nagavarakishore;Tabar, Viviane;Dunphy, Mark P.;Taldone, Tony;Shimizu, Fumiko;Chiosis, Gabriela research published 《 Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system》, the research content is summarized as follows. Diseases are a manifestation of how thousands of proteins interact. In several diseases, such as cancer and Alzheimer′s disease, proteome-wide disturbances in protein-protein interactions are caused by alterations to chaperome scaffolds termed epichaperomes. Epichaperome-directed chem. probes may be useful for detecting and reversing defective chaperomes. Here we provide structural, biochem., and functional insights into the discovery of epichaperome probes, with a focus on their use in central nervous system diseases. We demonstrate on-target activity and kinetic selectivity of a radiolabeled epichaperome probe in both cells and mice, together with a proof-of-principle in human patients in an exploratory single group assignment diagnostic study. The clin. study is designed to determine the pharmacokinetic parameters and the incidence of adverse events in patients receiving a single microdose of the radiolabeled probe administered by i.v. injection. In sum, we introduce a discovery platform for brain-directed chem. probes that specifically modulate epichaperomes and provide proof-of-principle applications in their use in the detection, quantification, and modulation of the target in complex biol. systems.
103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, Reference of 103-76-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics