The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. 103-76-4, formula is C6H14N2O, Name is N-(2-Hydroxyethyl)piperazine. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Computed Properties of 103-76-4.
Abba, Chiranjeevi;Puram, Naveen;Betala, Sailu research published 《 Synthesis of novel amide functionalized pyrido[2,3-d]pyrimidine derivatives and their anticancer activity》, the research content is summarized as follows. A series of novel amide functionalized pyrido[2,3-d]pyrimidine derivatives I (R = hydrazinyl, methylaminyl, 4-methylpiperazin-1-yl, etc.) were synthesized from 2-amino-6-(thiophen-2-yl)-4-(trifluoromethyl) nicotinonitrile, which on reaction with trifluoroacetic acid gets II. Compound II, treated with bromoethyl acetate followed by hydrazine hydrate, get hydrazide derivatives I (R = hydrazinyl). Compound I (R = hydrazinyl) on reaction with different substituted aromatic aldehydes R1CHO (R1 = Ph, 4-methylphenyl, 3-methoxyphenyl, etc.) to obtains Schiff base derivatives III. In another way, compound IV treated with different substituted amines such as methanamine, furan-2-ylmethanamine, piperidine, etc. and amino acids such as 2-aminoacetic acid, 2-aminopropanoic acid and 2-amino-3-phenylpropanoic acid to obtain amide derivatives I. All the compounds I and III evaluated for anti-cancer activity against four human cancer cell lines such as A549-Lung cancer (CCL-185), MCF7-Breast cancer (HTB-22), DU145-prostate cancer (HTB-81) and HeLa-cervical cancer (CCL-2) and among the synthesized compounds, only III (R1 = 4-chlorophenyl), I (R = 4-(2-hydroxyethyl)piperazin-1-yl; and R = (carboxy)methylaminyl) were identified as the potent compounds against the anticancer activity.
Computed Properties of 103-76-4, 1-(2-Hydroxyethyl)piperazine is a useful research compound. Its molecular formula is C6H14N2O and its molecular weight is 130.19 g/mol. The purity is usually 95%.
1-(2-Hydroxyethyl)piperazine is a chemical solvent that is used for the absorption of amines and other compounds. It has been shown to have a high affinity for acidic substances, which may be due to its ability to form hydrogen bonds with them. 1-(2-Hydroxyethyl)piperazine is also used in sample preparation for the analysis of amines and other compounds in fruit extracts. The solubility of 1-(2-Hydroxyethyl)piperazine depends on the experimental conditions, including pH, temperature, and pressure. FT-IR spectroscopy has been used to measure the vibrational modes of 1-(2-Hydroxyethyl)piperazine molecules. The IR spectrum revealed that this compound contains a hydroxyl group and two fatty acid chains with one or more hydroxyl groups at their terminal end. The nmr spectrum showed that 1-(2-Hydroxyethyl)piperazine contains an NH proton as well as, 103-76-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics