Month: April 2022

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《An improved rhodium-DIOP catalyst system for the homogeneous asymmetric hydrogenation of acetophenone》. Authors are Chan, Albert S. C.; Landis, Clark R..The article about the compound:(S)-1-(Dimethylamino)propan-2-olcas:53636-17-2,SMILESS:C[C@H](O)CN(C)C).Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol. Through the article, more information about this compound (cas:53636-17-2) is conveyed.

Optical yields as high as 79% were obtained in the title reaction when a rhodium-DIOP-chloride catalyst system containing a tertiary hydroxyalkylamine promoter was used. The various factors governing the rates and selectivities are discussed.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Recommanded Product: Potassiumtris(1-pyrazolyl)borohydride. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about Two new scorpionates vanadium haloperoxidases model complexes: Synthesis and structure of VO(O2)(pzH)(HB(pz)3) and VO(O2)(pzH)(B(pz)4) (pzH = pyrazole (C3H4N2)).

Using vanadium sulfate, H2O2, poly(1H-pyrazol-1-yl)borate and pyrazole as starting materials, two new neutral peroxovanadium(V) complexes with poly(1H-pyrazol-1-yl)borate, VO(O2)(pzH)(HB(pz)3) (1) and VO(O2)(pzH)(B(pz)4) (2), were synthesized. Both complexes were characterized by elemental anal., IR, UV-visible and NMR spectra. The structure of complex 1 was determined by x-ray diffraction, which is somewhat relevant for haloperoxidase enzymes. Cytotoxic effects also are discussed on 3T3 cell proliferation. In the concentration range (0.1-100 μmol), both complexes have an inhibiting cellular proliferation effect. For the cells cultivated with the complexes at high dose, the toxicity effect of both complexes is more predominant. Thermal decomposition kinetics and quantum chem. calculations of complex 1 were also performed.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Shu-Ju; Zhang, Zhi-Qing; Jiang, Yi-Hui; Xiong, Gang; You, Li-Xin; Ding, Fu; Dragutan, Ileana; Dragutan, Valerian; Sun, Ya-Guang researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Name: 1,10-Phenanthroline.They published the article 《Versatile monometallic coordination polymers constructed from 4,4′-thiobis(methylene)bibenzoic acid and 1,10-phenanthroline. Synthesis, structure, magnetic and luminescence properties》 about this compound( cas:66-71-7 ) in Inorganica Chimica Acta. Keywords: preparation monometallic transition metal thiobismethylenebibenzoate phenanthroline coordination polymeric complex; crystal structure transition metal thiobismethylenebibenzoate phenanthroline coordination polymeric complex; thermal decomposition transition metal thiobismethylenebibenzoate phenanthroline coordination polymeric complex; fluorescence transition metal thiobismethylenebibenzoate phenanthroline coordination polymeric complex; magnetic property transition metal thiobismethylenebibenzoate phenanthroline coordination polymeric complex. We’ll tell you more about this compound (cas:66-71-7).

Four novel mononuclear coordination polymers [Co(tmba)(phen)(H2O)0.5]n (1), [Mn(tmba)(phen)]n (2), [Zn(tmba)(phen)]n (3) and [Cd(tmba)(phen)(H2O)]n (4), H2tmba = 4,4′-thiobis(methylene)bibenzoic acid, phen = 1,10-phenanthroline, were synthesized under hydrothermal conditions and characterized by single crystal X-ray diffraction, powder X-ray diffraction, IR spectroscopy, and TGA. Single crystal X-ray diffraction showed that compounds 1, 3 and 4 build 1D chains whereas complex 2 displays a 2D layer configuration. Magnetic susceptibility measurements indicate that compound 1 exhibits the coexistence of spin-orbit coupling and antiferromagnetic interaction in the binuclear Co(II) center. Compound 2 manifests an antiferromagnetic interaction within the Mn(II)-carboxyl chain. Moreover, based on the solid state emission spectra of compounds 3 and 4, and of H2tmba and phen, relevant fluorescence properties were studied.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 53562-86-0, is researched, Molecular C5H10O3, about Enantioselective hydrogenation of β-keto esters with monodentate ligands, the main research direction is keto ester hydrogenation ruthenium chiral monodentate phosphine; hydroxy ester asym preparation; ruthenium chiral monodentate phosphine asym hydrogenation catalyst.Product Details of 53562-86-0.

Efficient and stable chiral monodentate phosphine ligands can be used in the ruthenium-catalyzed enantioselective hydrogenation of β-keto esters. The catalysts were remarkably temperature-tolerant, and high enantioselectivities were possible, even at 100-120°C.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(Bromomethyl)-4-iodobenzene(SMILESS: IC1=CC=C(CBr)C=C1,cas:16004-15-2) is researched.Product Details of 1265884-98-7. The article 《Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:16004-15-2).

The design, synthesis, and evaluation of a series of 1-oxa-8-azaspiro[4.5]decane I (R = F, I, OCH2CH2F) and 1,5-dioxa-9-azaspiro[5.5]undecane derivatives II (R = F, I, OCH2CH2F, OMe) as selective σ1 receptor ligands has been reported. All seven ligands exhibited nanomolar affinity for σ1 receptors (Ki(σ1) = 0.47 – 12.1 nM) and moderate selectivity over σ2 receptors (Ki(σ2)/ Ki(σ1) = 2 – 44). Compound I (R = OCH2CH2F), with the best selectivity among these ligands, was selected for radiolabeling and further evaluation. Radioligand II (R = OCH2CH2F18) was prepared via nucleophilic 18F-substitution of the corresponding tosylate precursor, with an overall isolated radiochem. yield of 12-35%, a radiochem. purity of greater than 99%, and molar activity of 94 – 121 GBq/μmol. Biodistribution studies of II (R = OCH2CH2F18) in mice demonstrated high initial brain uptake at 2 min. Pretreatment with SA4503 resulted in significantly reduced brain-to-blood ratio (70% – 75% at 30 min). Ex vivo autoradiog. in ICR mice demonstrated high accumulation of the radiotracer in σ1 receptor-rich brain areas. These findings suggest that II (R = OCH2CH2F18) could be a lead compound for further structural modifications to develop potential brain imaging agents for σ1 receptors.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Product Details of 53562-86-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Microreactors and microfluidic reactors for synthesis of fine chemicals. Author is Kluson, P.; Stavarek, P.; Hejda, S.; Penkavova, V.; Bendova, M.; Vychodilova, H..

The primary intention of this work was to bring information on the research, development, and construction of advanced microreactor platforms for the syntheses of fine chems. A brief overview was provided on the systems used for practical gas and liquid phase reactions, homogeneous and heterogeneous catalytic reactions, polymerizations, and also for reactions with involvement of light. Then an attention was paid to the tubular continuous microreactors, especially to those which are usually referred to as microfluidic chips. In the past, these microfluidic reactors have been used for various organic reactions in the field of fine chem. Finally, an algorithm has been described for a validation of the microtluidic reactor platform for flow conditions of specific solvents mixtures used in stereoselective hydrogenation of β-ketoesters with chiral metal complexes, and in the presence of specific ionic liquids

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Organometallics called Acceptorless Dehydrogenation of N-Heterocycles and Secondary Alcohols by Ru(II)-NNC Complexes Bearing a Pyrazoyl-indolyl-pyridine Ligand, Author is Wang, Qingfu; Chai, Huining; Yu, Zhengkun, which mentions a compound: 2343-22-8, SMILESS is FC1=CC2=C(NCC2)C=C1, Molecular C8H8FN, Name: 5-Fluoroindoline.

Ru(II) hydride complexes bearing a pyrazolyl-(2-indol-1-yl)-pyridine ligand were synthesized and structurally characterized by NMR anal. and x-ray single crystal crystallog. determinations These complexes efficiently catalyzed acceptorless dehydrogenation of N-heterocycles and secondary alcs., resp., exhibiting highly catalytic activity with a broad substrate scope. The present work established a strategy to construct highly active transition-metal complex catalysts, and provides an atom-economical and environmentally benign protocol for the synthesis of aromatic N-heterocyclic compounds and ketones.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Karrer, Friedrich; Kayser, Hartmut; Buser, Hans Peter; Ramos Tombo, Gerardo M. published the article 《Insect juvenile hormone mimics: a chemical metamorphosis from terpenoid esters to aryloxy dioxolanes》. Keywords: insect juvenile hormone aryloxy dioxolane mimic.They researched the compound: 2-Bromopriopionaldehydediethylacetal( cas:3400-55-3 ).Name: 2-Bromopriopionaldehydediethylacetal. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3400-55-3) here.

The 1,3-dioxolane derivative I is a potent juvenile hormone mimic. The stereoselective synthesis of its stereoisomers (2R,4S)-, (2S,4R)-, (2S,4S)-, and (2R,4R)-I was based on the chiral glycerol derivative II. Three different approaches to this central compound were investigated: using chiral building blocks, enantioselective catalytic hydrogenation, and stereoselective crystallization The latter is the most suitable for large scale synthesis. In vivo testing of the different stereoisomers on Nauphoeta cinerea showed that the juvenoid activity is mainly associated with the (2R,4S)-I isomer.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

COA of Formula: C8H8FN. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Synthesis and cytotoxicity evaluation of novel 5-fluorinated indoles. Author is Budovska, Mariana; Krochtova, Kristina; Kuba, Miroslav; Tischlerova, Viera; Mojzis, Jan.

Authors report herein the synthesis of a small 28-membered library of novel 5-fluorinated indole phytoalexins. Target compounds were designed by a structure-based bioisosterism strategy. The newly prepared compounds were screened in vitro for cytotoxic activity against seven human cancer cell lines. The cytotoxic evaluation revealed that the 2′-(3,4-dichlorophenylamino) analog of 5-fluorospirobrassinin was the most active against cancer cell lines without causing toxicity to HUVEC cells. Overall, 5-fluoro analogs of indole phytoalexins did not show improved anti-cancer activity compared to the lead compounds The preliminary structure-activity relationship (SAR) study revealed that placing fluoro substituent at C-5 position of the indole ring is not crucial for inducing cytotoxicity against a cancer cell line.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

COA of Formula: C8H8FN. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Re-Catalyzed Annulations of Weakly Coordinating N-Carbamoyl Indoles/Indolines with Alkynes via C-H/C-N Bond Cleavage.

A rhenium-catalyzed [3+2] annulations of N-carbamoyl indoles with alkynes via C-H/C-N bond cleavage, provided rapid access to fused-ring pyrroloindolone derivs I [R1 = H, 6-F, 7-Br, etc.; R2 = R3 = Ph, 4-MeC6H4, 1-naphthyl, etc.]. For the first time, the weakly coordinating O-directing group was successfully employed in rhenium-catalyzed C-H activation reactions, enabled by the unique catalytic ratio of Re2(CO)10, Me2Zn and ZnCl2. Mechanistic studies revealed that aminozinc species played an important role in the reaction. Based on the mechanistic understanding, a more powerful catalytic ratio of Re2(CO)10, [MeZnNPh2]2 and Zn(OTf)2 was devised and applied successfully in the [4+2] annulations of indolines and alkynes affording pyrroloquinolinone derivs II.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics