Month: April 2022

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Methyl 3-hydroxybutanoate(SMILESS: C[C@H](O)CC(OC)=O,cas:53562-86-0) is researched.Application of 54903-09-2. The article 《New chiral phospholanes; synthesis, characterization, and use in asymmetric hydrogenation reactions》 in relation to this compound, is published in Tetrahedron: Asymmetry. Let’s take a look at the latest research on this compound (cas:53562-86-0).

The practical synthesis of enantiomerically pure trans-2,5-disubstituted-1-phenylphospholanes, e.g., I, which are then employed in the preparation of a new series of C2-sym. bis-, e.g., II, and C3-sym. tris(phospholane) ligands, is described. A versatile three-step route to the important chiral 1,4-diol intermediates, e.g., III, used in the phosphine syntheses, is outlined. Rhodium complexes bearing the new phosphine ligands were prepared and shown to act as efficient catalyst precursors for the enantioselective hydrogenation of various unsaturated substrates. The crystal structure of 3 of the prepared Rh complexes were determined

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Alkoxyphenyl methanesulfonamides: synthesis, anti-inflammatory effect, and docking studies.Application of 54903-09-2.

A series of 2-alkoxyphenyl methanesulfonamide-based compounds were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model. The compounds 4-7 showed comparable anti-inflammatory activity to rofecoxib and indomethacin, the standard drugs taken in both the studies. The synthesized compounds were also investigated for their gastric ulcerogenic potential and found to be non-ulcerogenic at the test doses. In silico (docking studies) were done to investigate the hypothetical binding mode of the target compounds to the cyclooxygenase isoenzyme (COX-2). A binding model has been proposed based on the docking studies to explain the observed pharmacol. activity of the test compounds Selected physicochem. parameters for the target compounds suggest good drug transport properties and potential bioavailability.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic Route of C5H10O3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Stereoselective Synthesis of Premisakinolide A, the Monomeric Counterpart of the Marine 40-Membered Dimeric Macrolide Misakinolide A. Author is Nakamura, Ryoichi; Tanino, Keiji; Miyashita, Masaaki.

The first synthesis of protected premisakinolide A (I), the monomeric counterpart of misakinolide A, the marine 40-membered macrolide displaying potent activity against a variety of human carcinoma cell lines (no data), has been reported. The strategy was highlighted by a crucial coupling of a tetrahydropyran fragment and an alkynylaluminum reagent having a polypropionate chain, the highly stereoselective cross aldol reaction of segment A and segment B, and the stereospecific construction of the polypropionate structure based on original acyclic stereocontrol.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Synthesis and Characterization of a Specific Iodine-125-Labeled TRPC5 Radioligand, the main research direction is preparation iodine 123 TRPC5 radioligand PET imaging; Ca2+ imaging; PET tracers; TRPC5; autoradiography; iodine; radioligands.Recommanded Product: 16004-15-2.

The nonselective Ca2+-permeable transient receptor potential channel subfamily member 5 (TRPC5) belongs to the transient receptor potential canonical (TRPC) superfamily and is widely expressed in the brain. Compelling evidence reveals that TRPC5 plays crucial roles in depression and other psychiatric disorders. To develop a TRPC5 radioligand, following up on our previous effort, we synthesized the iodine compound TZ66127 and its iodine-125-labeled counterpart [125I]TZ66127. The synthesis of TZ66127 was achieved by replacing chloride with iodide in the structure of HC608, and the [125I]TZ66127 was radiosynthesized using its corresponding tributylstannylated precursor. We established a stable human TRPC5-overexpressed HEK293-hTRPC5 cell line and performed Ca2+ imaging and a cell-binding assay study of TZ66127; these indicated that TZ66127 had good inhibition activity for TRPC5, and the inhibitory efficiency of TZ66127 toward TRPC5 presented in a dose-dependent manner. An in vitro autoradiog. and immunohistochem. study of rat brain sections suggested that [125I]TZ66127 had binding specificity toward TRPC5. Altogether, [125I]TZ66127 has high potential to serve as a radioligand for screening the binding activity of other new compounds toward TRPC5. The availability of [125I]TZ66127 might facilitate the development of therapeutic drugs and PET imaging agents that target TRPC5.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,10-Phenanthroline(SMILESS: C1=CC3=C(C2=NC=CC=C12)N=CC=C3,cas:66-71-7) is researched.HPLC of Formula: 54903-09-2. The article 《Synthesis and photophysical properties of metal complexes of curcumin dyes: Solvatochromism, acidochromism, and photoactivity》 in relation to this compound, is published in Dyes and Pigments. Let’s take a look at the latest research on this compound (cas:66-71-7).

Curcumin and its dyes have attracted attention due to their environment-sensitivity and optical properties. However, the free mol. has low photoactivity, which is a limitation for use in photodynamic therapy. To overcome this limitation, we proposed the chelation of a D-π-A-π-D curcumin dye (1) with the metals Cu (II) and Pd (II). The photophys. properties of the curcumin dyes were investigated in different solvents, using UV-vis spectroscopy and time-resolved/steady-state fluorescence techniques. In our results, all curcumin dyes exhibited a pos. solvatochromism from non-polar to polar solvents, with the Stokes’ shift in the range of 1895-4970 cm-1. The acidochromism studies were performed in chloroform solution and TLC plates using trifluoroacetic acid (TFA). The results exhibited a neg. acidochromism and fluorescence quenching upon gradual addition of TFA, demonstrating reversibility upon addition of triethylamine (TEA). The main mechanism which influences the solvatochromism/acidochromism is the ICT system and fluorescence lifetime decays exhibited mono-exponential fit for aprotic solvents and bi-exponential fit for protic solvents (EtOH and MeOH). Compared to the curcumin ligand (1), the metal complexes (1a-b) exhibited higher singlet oxygen quantum yields (ΦΔ = 0.36 and 0.54, resp.). The in vitro antimicrobial photoactivity of the compounds was evaluated against six different microorganisms. The results showed that the metal complexes (1a-b) exhibited both antileishmanial (MIC = 2.29μM against Leishmania amazonensis promastigotes) and antifungal (IC50 = 10μM against Sporothrix brasiliensis yeasts) activities, while the ligand showed no activity, suggesting the chelation with the metals Cu (II) and Pd (II) may improve its photoactivity.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Aichaoui, Hocine; Poupaert, Jacques H.; Lesieur, Daniel; Henichart, Jean Pierre published the article 《Regioselectivity in the C-acylation of 2(3H)-benzoxazolones》. Keywords: benzoxazolone acylation regioselectivity; acylbenzoxazolone preparation NMR; acylaminophenol cyclocondensation urea.They researched the compound: 6-Acetylbenzo[d]oxazol-2(3H)-one( cas:54903-09-2 ).HPLC of Formula: 54903-09-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:54903-09-2) here.

C-acylation of benzoxazolone I (R = R1 = H) using either carboxylic acids R2CO2H and polyphosphoric acid as solvent and catalyst or under Friedel-Crafts conditions using acid halides or anhydrides in presence of AlCl3 in DMF gave only 6-acylbenzoxazolones I (R = H, R1 = COR2, R2 = Me, Et, CHBrMe, Ph, 2-thienyl). This observation contradicts previously published results. 5-Acylbenzoxazolones I (R = COR2, R2 as above, R1 = H) were prepared by the cyclocondensation of 4-acyl-2-aminophenols II (R2 as above) with urea. Proton NMR of 5- and 6-acylbenzoxazolones are reported.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Category: piperazines. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Synthesis of BINAP ligands with imidazole tags for highly enantioselective Ru-catalyzed asymmetric hydrogenation of β-keto esters in ionic liquid systems. Author is Jin, Xin; Kong, Fang-fang; Yang, Zhi-qiang; Cui, Fei-fei.

The imidazole-tagged BINAP ligands were synthesized and used for Ru-catalyzed asym. hydrogenation of β-keto esters in ionic liquid (IL) systems. The Ru-BINAP catalysts with the imidazolium tags show high catalytic activity and enantioselectivity, which closely parallel the performance of unmodified BINAP. The catalyst recycling experiments using [bmim]Tf2N/MeOH system demonstrated that introducing imidazolium moieties to the BINAP backbone can effectively enhance the affinity of the Ru-catalysts to the IL, reduce Ru leaching and improve catalysts stability, and after several cycles no significant loss of activity and enantioselectivity was observed

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Rampulla, David M.; Gellman, Andrew J. published an article about the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O ).Electric Literature of C5H10O3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:53562-86-0) through the article.

Of the three types of chiral surfaces described in this entry, the most well-developed ones are those that are produced by templating with chiral organic modifiers. Although the mechanisms and adsorbate/substrate interactions that impart enantioselectivity on these surfaces are not understood in great detail, some such surfaces have been highly optimized to give highly enantioselective separations and catalytic reactions. Naturally chiral surfaces can be generated from materials that are chiral in bulk, or achiral materials cleaved to expose surface structures that are chiral at the nanoscale. The crystalline nature of these structures makes them good candidates for a detailed study of the origins of enantiospecificity on their surfaces.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Preobrazhenskaya, M. N.; Mukhanov, V. I.; Kostyuchenko, N. P.; Suvorov, N. N. researched the compound: 5-Fluoroindoline( cas:2343-22-8 ).SDS of cas: 2343-22-8.They published the article 《Glycosylindoles. XI. Synthesis of 1-β-D-ribopyranosides of 5- and 6-fluoroindole》 about this compound( cas:2343-22-8 ) in Zhurnal Organicheskoi Khimii. Keywords: ribopyranosylindole fluoro; conformation ribopyranoside indole. We’ll tell you more about this compound (cas:2343-22-8).

Treatment of 6-fluoroindoline with D-ribose, followed by acetylation gave 72% 6-fluoro derivative (I; R = Ac, X = 6-F) which was dehydrogenated by heating with 2,3-dichloro-5,6-dicyanoquinone to give 44% of the indole derivative (II; R = Ac, X = 6-F). Deacetylation of the latter with Na-OMe-MeOH gave 97% 1-β-D-ribopyranosyl-6-fluoroindole (II; R = H, X = 6-F). Analogously prepared were the 5-fluoro derivatives and the corresponding α-D-anomers. Conformations of the ribopyranosyl group were determined by PMR.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 53562-86-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about A strategy for the stereoselective synthesis of unsymmetric atropisomeric ligands: preparation of NAPhePHOS, a new biaryl diphosphine.

MeO-NAPhePHOS (shown as I) represents the 1st example of atropisomeric diphosphines bearing heterotopic biaryl moieties. The key step of its synthesis is the diastereoselective, intramol., CuI-promoted coupling of 1-iodo-2-naphthol and 2-iodo-3-methoxyphenol connected by a chiral tether. (R,R)-2,4-Pentanediol was used as the chiral auxiliary in this highly selective reaction that leads to a single enantiomer of the title diphosphine. In the Ru-promoted hydrogenations of carbonyl derivatives, NAPhePHOS affords enantioselectivity levels fully comparable to those of the C2-sym. analogs, BINAP and MeO-BIPHEP, resp., thus showing that the lack of C2 symmetry is not detrimental to the catalytic properties of atropisomeric ligands in these hydrogenation reactions.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics