Month: April 2022

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Ligand-acceleration by a chiral modifier in the enantioselective hydrogenation of methyl acetoacetate on a Raney nickel catalyst: effect of a modifier configuration.Recommanded Product: 53562-86-0.

Reaction rate and enantioselectivity of asym. hydrogenation of Me acetoacetate were studied over Raneynickel catalysts modified with (R,R)-tartaric acid, malic acid, or succinic acid to reveal the impacts of the modifier configuration. Catalysts comodified with two different acids were also examined to confirm the conclusions. From anal. of the enantiomer ratio of the hydrogenation product and initial reaction rate, tartaric acid (TA) was found to have dual functions as the modifier during the hydrogenation; effective suppression of the racemic catalysis on bare Ni surface and extensive enantiodifferentiating ligand acceleration by adsorbed TA. It was demonstrated that each adsorbed chiral modifier mol. independently takes part in the enantiospecific hydrogenation.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 66-71-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Heteroleptic copper(II) complexes of prenylated flavonoid osajin behave as selective and effective antiproliferative and anti-inflammatory agents. Author is Vanco, Jan; Travnicek, Zdenek; Hosek, Jan; Dvorak, Zdenek.

Heteroleptic copper(II) complexes, containing prenylated flavonoid osajin isolated from the fruits of Maclura pomifera Schneid., were prepared and thoroughly characterized, including single crystal X-ray anal. Some of the following complexes of the general composition [Cu(L)(bpy)]NO3 (1), [Cu(L)(dimebpy)]NO3·2MeOH (2) [Cu(L)(phen)]NO3·H2O (3), [Cu(L)(bphen)]NO3 (4) and [Cu(L)(dppz)]NO3 (5), where HL stands for 3-(4-hydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-ene-1-yl)-4H,8H-benzo[1,2-b:3,4-b′]dipyran-4-one (osajin), bpy = 2,2′-bipyridine, dimebpy = 4,4′-dimethyl-2,2′-bipyridine, phen = 1,10-phenanthroline, bphen = 4,7-diphenyl-1,10-phenanthroline and dppz = dipyrido[3,2-a:2′,3′-c]phenazine, were also monitored for their solution stability and interactions with cysteine and glutathione by mass spectrometry. The in vitro cytotoxicity of the complexes was evaluated against a panel of eight human cancer cell lines: (MCF-7, HOS, A549, PC-3, A2780, A2780R, Caco-2, and THP-1). The results revealed high antiproliferative activity of the complexes with the best IC50 values of 0.5-3.4 μM for complexes (4) and (5), containing the bulkier N,N′-donor ligands (bphen, and dppz, resp.). The complexes also revealed a relatively low toxicity towards human hepatocytes (IC50 values are higher than 100 μM in some cases), and thus proved to be highly selective towards the cancer cells. On the other hand, the complexes showed a strong in vitro nuclease effect using the model pUC-19 plasmid. In the model of lipopolysaccharide-stimulated (LPS) THP-1 monocytes, the complexes revealed ability to lower the activity of nuclear factor kappa-B/activator protein 1 (NF-κB /AP-1) system and decrease the secretion of tumor necrosis factor alpha (TNF-α). Thus, the complexes have been identified as strong antiproliferative and anti-inflammatory compounds

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of 1-(Bromomethyl)-4-iodobenzene. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Discovery of novel indole-1,2,4-triazole derivatives as tubulin polymerization inhibitors. Author is Wu, Meng-Ke; Man, Ruo-Jun; Liao, Yan-Juan; Zhu, Hai-Liang; Zhou, Zhu-Gui.

A series of novel indole-1,2,4-triazole derivatives have been designed, synthesized, and evaluated as potential tubulin polymerization inhibitors. The top hit 12, bearing the 3,4,5-trimethoxyphenyl moiety, exhibited substantial anti-proliferative activity against HepG2, HeLa, MCF-7, and A549 cells in vitro with IC50 values of 0.23 ± 0.08μM, 0.15 ± 0.18μM, 0.38 ± 0.12μM, and 0.30 ± 0.13μM, resp. It also inhibited tubulin polymerization with the IC50 value of 2.1 ± 0.12μM, which was comparable with that of the pos. controls. Furthermore, compound 12 regulated the expression of cell cycle-related proteins (Cyclin B1, Cdc25c, and Cdc2) and apoptosis-related proteins (Bcl-2, Bcl-x, and Mcl-1). Mechanistically, compound 12 could arrest cell cycle at the G2/M phase, thus induce an increase of apoptotic cell death. In addition, mol. docking hinted the possible interaction mode of compound 12 into the colchicine binding site of tubulin heterodimers. According to the applications of microtubule-targeting agents in both direct and synergistic cancer therapies, we hope this work might be of significance for future researches.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 66-71-7, is researched, SMILESS is C1=CC3=C(C2=NC=CC=C12)N=CC=C3, Molecular C12H8N2Journal, Article, International Journal of Biological Macromolecules called Lignin-based fluorescence-switchable graphene quantum dots for Fe3+ and ascorbic acid detection, Author is Zhu, Lingyan; Li, Dongbing; Lu, Heng; Zhang, Shangkun; Gao, Hao, the main research direction is lignin fluorescence graphene quantum dot ascorbic acid detection; Alkali lignin; Fluorescence sensing; Graphene quantum dots.Quality Control of 1,10-Phenanthroline.

The synthesis of lignin-based graphene quantum dots (GQDs) with excellent fluorescence stability, quantum yield, and biocompatibility for sensitive and selective detection of Fe3+ and ascorbic acid (AA) has remained a challenging endeavor. Using an acidolysis process with 17.5% nitric acid followed by hydrothermal treatment at 200 °C, this study provided an improved synthesis route for the production of high-quality GQDs from alkali lignin. The nitrogen-doped GQDs exhibit remarkable fluorescence stability under a wide range of pH (3-10), duration (1-12 h), and [NaCl] (0-1000 mM) conditions, and have a high quantum yield of 28%. The GQDs or GQDs/Fe3+ sensing systems ([GQDs] at 50 mg L-1, [Fe3+] at 500 °mol L-1, and UV excitation at 370 nm) for fluorescence sensing of Fe3+ or AA have excellent sensitivity, selectivity, and reproducibility. For Fe3+ and AA, the limit of detection is 1.49 and 1.62 °mol L-1, resp. Mechanism investigation shows that photoluminescence quenching is caused by the formation of GQDs-Fe3+ complexes, whereas fluorescence recovery is due to Fe3+ reduction by AA.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Phenanthroline bridging graphitic carbon nitride framework and Fe (II) ions to promote transfer of photogenerated electrons for selective photocatalytic reduction of Nitrophenols, the main research direction is phenanthroline graphitic carbon nitride nitrophenol photocatalytic reduction; Fe (II); Graphitic carbon nitride; Nitrophenols; Phenanthroline; Selective reduction.Formula: C12H8N2.

Nitrophenols (NPs) are widely used in industries and highly toxic to ecol. environment and human health. Because aminophenols (APs) are important chems., catalytic reduction of NPs via efficient and environment-friendly strategies is of great importance. Herein, we developed a green photocatalysis route to efficiently convert NPs to APs using a Fe (II) modified graphitic carbon nitride (g-C3N4) photocatalyst, where phenanthroline units were employed to bridge Fe (II) and carbon nitride framework. The optimized sample P-CN-8-Fe presented significantly improved absorption of visible light, separation of photogenerated charges and carrier transportation in comparison with the pristine g-C3N4 and the modified samples of CN-Fe and P-CN-8. Accordingly, the P-CN-8-Fe showed a high conversion (97%) of p-nitrophenol (p-NP) to p-aminophenol (p-AP) under 2 h visible light irradiation, and meanwhile possessed high photocatalytic durability. Its high activity was also demonstrated through photocatalytic reduction of other NPs and nitrobenzene compounds Finally, a possible mechanism was proposed for the photocatalytic reduction of p-NP by P-CN-8-Fe. This work provides an effective approach to prepare Fe (II) modified g-C3N4 through the bridging effect of phenanthroline group, which is a potential visible light driven photocatalyst for reduction of nitrobenzene derivatives

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Potassiumtris(1-pyrazolyl)borohydride(SMILESS: [BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+],cas:18583-60-3) is researched.Quality Control of (S)-1-(Dimethylamino)propan-2-ol. The article 《Photoluminescence studies on europium-based scorpionate-complex》 in relation to this compound, is published in Inorganic Chemistry Communications. Let’s take a look at the latest research on this compound (cas:18583-60-3).

The neutral homoleptic Eu(III) complex Eu(Tp)3 (Tp = hydrotris(pyrazol-1-yl)borate) showed luminescence associated to f-f transitions if irradiated with near-UV radiation having wavelength <380 nm. In this species the most intense emission corresponds to the 5D0 → 7F4 transition, falling between 690 and 700 nm. The complex is stable towards oxygen, moisture and near-UV light. The energy levels of the coordinated ligands involved in the photoluminescence process were computed by applying computational methods and by carrying out luminescence measurements on the analogous Gd(III) complex. As far as I know, this compound(18583-60-3)Safety of Potassiumtris(1-pyrazolyl)borohydride can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-1-(Dimethylamino)propan-2-ol, is researched, Molecular C5H13NO, CAS is 53636-17-2, about A dissymmetric molecular capsule with polar interior and two mechanically locked hemispheres.Quality Control of (S)-1-(Dimethylamino)propan-2-ol.

The synthesis and chiral resolution of a dissym. tetraurea-calix[4]pyrrole/tetraurea-calix[4]arene mol. capsule with two hemispheres mech. locked is described. The assembly features a bis-[2]catenated topol. and shows reversible mol. co-encapsulation of two different neutral mols. or two oppositely charged ions.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bagnall, K. W.; Edwards, J.; Heatley, F. researched the compound: Potassiumtris(1-pyrazolyl)borohydride( cas:18583-60-3 ).Computed Properties of C9H10BKN6.They published the article 《Uranium(IV) poly(pyrazol-1-yl)borate complexes – carbon-13 NMR spectra》 about this compound( cas:18583-60-3 ) in Transplutonium 1975, Proc. Int. Transplutionium Elem. Symp., 4th. Keywords: NMR carbon uranium pyrazolylborate; borate pyrazolyl uranium NMR. We’ll tell you more about this compound (cas:18583-60-3).

13C NMR spectra were obtained for K[HB(Pz)3], UCl2[HB(Pz)3]2 (I), U[HB(Pz)3]4 (II), and (η-C5H5)UCl2[HB(Pz)3] (III) (Pz = pyrazol-1-yl) and the assignments are discussed. Two distinct sets of C resonances were observed in the spectrum of I, the 2 sets being in the ratio 2:1, indicating that the [HB(Pz)3] ligand is bidentate in this complex. There are no large chem. shifts, consistent with the major contribution to proton shift being due to the pseudo-contact mechanism, which depends largely on distance. The spectrum of II can only be assigned in terms of 10-coordinate U, based on the presence of 2 tridentate and 2 bidentate [HB(Pz)3] groups in the mol. The spectrum of III did not show any very large chem. shifts assignable to pyrazole ring C. The 3 sharp resonances at 121.0, 126.0, and 130.6 ppm were assigned to the C atoms of the pyrazole rings of the tridentate pyrazolylborate ligand, and the broad feature centered ∼280 ppm is probably due to the 5 equivalent C atoms of the cyclopentadienyl ring.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Fluoroindoline(SMILESS: FC1=CC2=C(NCC2)C=C1,cas:2343-22-8) is researched.Quality Control of 1,10-Phenanthroline. The article 《Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors》 in relation to this compound, is published in ACS Chemical Neuroscience. Let’s take a look at the latest research on this compound (cas:2343-22-8).

Activation of HIF-1α and Nrf2 is a primary component of cellular response to oxidative stress, and activation of HIF-1α and Nrf2 provides neuroprotection in models of neurodegenerative disorders, including ischemic stroke, Alzheimer’s and Parkinson’s diseases. Screening a library of CNS-targeted drugs using novel reporters for HIF-1α and Nrf2 elevation in neuronal cells revealed histone deacetylase (HDAC) inhibitors as potential activators of these pathways. We report the identification of phenylhydroxamates as single agents exhibiting tripartite inhibition of HDAC6, inhibition of HIF-1 prolyl hydroxylase (PHD), and activation of Nrf2. Two superior tripartite agents, ING-6 and ING-66, showed neuroprotection against various cellular insults, associated with stabilization of both Nrf2 and HIF-1, and expression of their resp. target genes in vitro and in vivo. Discovery of the innate ability of phenylhydroxamate HDAC inhibitors to activate Nrf2 and HIF provides a novel route to multifunctional neuroprotective agents and cautions against HDAC6 selective inhibitors as chem. probes of specific HDAC isoform function.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Abdel-Rahman, Laila H.; Basha, Maram T.; Al-Farhan, Badriah Saad; Ismael, Mohamed published an article about the compound: 1,10-Phenanthroline( cas:66-71-7,SMILESS:C1=CC3=C(C2=NC=CC=C12)N=CC=C3 ).Quality Control of 1,10-Phenanthroline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:66-71-7) through the article.

The emergence of drug-resistant pathogens has greatly limited the use of antibiotics in treating microbial infections. Therefore, Cu complexes have emerged as potential alternatives to ordinary antibiotics. Ternary Cu(II) complexes with N-benzoyl-DL-phenylalanine (Bzphe) and imidazole (Imi), methylimidazole (Mimi), 2,2′-bipyridine (Bipy), and 1,10-phenanthroline (Phen) ligands were prepared and investigated for antimicrobial efficacy against two Gram-pos. bacteria (Bacillus subtilis and Micrococcus luteus), one Gram-neg. bacteria (Escherichia coli), and three fungal cultures (Aspergillus niger, Candida glabrata, and Saccharomyces cerevisiae). The new complexes were characterized by elemental anal., IR spectroscopy, electronic spectroscopy, thermogravimetry, and measurements of their molar conductivity and m.p. The formulas of the new complexes were Cu(Bzphe)2(Imi)2(OH2)2, [Cu(Bzphe)2(Mimi)2(OH2)2], Cu(Bzphe)2(Bipy)(OH2)2, and Cu(Bzphe)2(Phen)(OH2)2. The obtained data revealed that the Bzphe invariably coordinates to the Cu(II) ions through carboxylic oxygen as a monobasic ligand. The addition of secondary ligands such as amines does not affect the unidentate coordination behavior of the Bzphe. The new compounds were screened for antimicrobial activity against different strains of bacteria and fungi. The results for the Bzphe ligand and its mixed-ligand Cu(II) complexes showed that the ligands exhibit low potency to inhibit the growth of both Gram-pos. bacteria (B. subtilis and M. luteus) and Gram-neg. bacteria (E. coli). However, the new ternary complexes greatly suppressed the growth of these pathogens according to the order CuBipyBzphe > CuPhenBzphe > CuMimiBzphe > CuImiBzphe. In addition, computational studies using d. functional theory calculations and mol. docking experiments were carried out to characterize the mol. properties of the new complexes and provide insights into their role in inhibiting the growth of bacterial and fungal strains.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics