Month: April 2022

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yang, Ren-Yin; Wang, Hui; Xu, Bo researched the compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ).Quality Control of 1-(Bromomethyl)-4-iodobenzene.They published the article 《Base promoted gem-difluoroolefination of alkyl triflones》 about this compound( cas:16004-15-2 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: difluoroalkene preparation; alkyl triflone bromodifluoromethyl trimethylsilane difluoroolefination lithium iodide catalyst. We’ll tell you more about this compound (cas:16004-15-2).

A new synthesis of gem-difluoroalkenes ArC(R)=CF2 [Ar = 4-bromophenyl, naphthalen-2-yl, 5-(methoxycarbonyl)thiophen-2-yl, etc.; R = prop-2-en-1-yl, 3-phenylprop-2-yn-1-yl, (4-methylphenyl)methyl, etc.] from readily available alkyl triflones ArCH(R)S(O)2CF3 and difluorocarbene precursors such as TMSCF2Br has been reported. The reaction, regardless of electronic effect, gives gem-difluoroalkenes ArC(R)=CF2 in good to excellent yields. The mechanism may involve deprotonation of triflones, nucleophilic addition, and the elimination of SO2CF3.

In some applications, this compound(16004-15-2)Quality Control of 1-(Bromomethyl)-4-iodobenzene is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Piperazine – Wikipedia,
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Application In Synthesis of 1,10-Phenanthroline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Preparation, spectroscopic characterization and antitumor-antimicrobial studies of some Schiff base transition and inner transition mixed ligand complexes. Author is Khalil, Eman A. M.; Mohamed, Gehad G..

Mixed ligand complexes of Mn(II), Ni(II), Zn(II), La(III), Er(III) and Yb(III) metal ions were prepared from bidentate Schiff base ligand (L) as a primary ligand, derived from condensation of benzophenone and 1,8-naphthylenediamine, and 1,10-phenanthroline (Phen) as a secondary ligand. The new Schiff base ligand (N1-(diphenylmethylene)naphthalene-1,8-diamine) and its mixed ligand complexes were characterized by using elemental microanal., conductometric measurements, magnetic susceptibility and spectroscopic studies (UV-Vis, mass spectral anal., IR, 1H NMR and SEM). In addition, their thermal anal. (TG and DTG) behavior has been reported. Measurements of the molar conductivity of the complexes in DMF solvent pointed out the electrolytic nature of all complexes except Mn(II) and Zn(II) complexes were non electrolytes. According to the elemental analyses data, it was observed that the mixed ligand chelates had the general formulas [M(L)(Phen)Cl2]Cl.2H2O (M = La(III), Er(III) and Yb(III)), [M(L)(Phen)Cl2].H2O (M = Mn(II) and Zn(II)) and [Ni(L)(Phen)Cl(H2O)]Cl.H2O. Based on these findings, all mixed ligand complexes had octahedral geometry. The SEM image of the Schiff base ligand illustrated its rods like morphol. with and average particle size of 77 nm while, the image of Ni(II) complex showed non-uniform platelets structure with some scattered rods with an average particle size of 54 nm. Considerable applications were done to ensure the biol. significance of Schiff base ligand and its new mixed ligand complexes with Phen against Gram-neg. bacteria (Escherichia coli), Gram-pos. bacteria (Bacillus subtilis) and fungal (Aspergillus flavus and Candida albicans) strains and anti-cancer activities against (MCF7 breast cancer cell line). The results obtained revealed that the complexes exhibited promising biol. and anticancer activity. Moreover, mol. docking studies were applied to determine the probable binding mode among the Schiff base ligand and the active site of the crystal structure of E. coli YcbB acylated with meropenem (PDB ID: 6NTW) and breast cancer estrogen mutant L536S (PDB ID: 6SBO) receptors.

In some applications, this compound(66-71-7)Application In Synthesis of 1,10-Phenanthroline is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Computed Properties of C7H6BrI. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-iodobenzene, is researched, Molecular C7H6BrI, CAS is 16004-15-2, about Environmentally benign nucleophilic substitution reaction of arylalkyl halides in water using CTAB as the inverse phase transfer catalyst. Author is Godha, Atul K.; Thiruvengadam, Jayaraman; Abhilash, Viswanadhan; Balgi, Prajwal; Narayanareddy, A. V.; Vignesh, Kumaresan; Gadakh, Amol V.; Sathiyanarayanan, A. M.; Ganesh, Sambasivam.

An environmentally benign, practically scalable and highly selective C-arylalkylation of active methylene compounds is developed using CTAB as the inverse phase transfer catalyst in water. The methodol. developed is elaborated into the one-pot synthesis of quinoline derivatives and also applicable to the regioselective N-aralkylation of 2-pyridones.

In some applications, this compound(16004-15-2)Computed Properties of C7H6BrI is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Base catalysis in the Willgerodt-Kindler reaction, the main research direction is Willgerodt Kindler reaction triethylamine solvent; methoxyacetophenone Willgerodt Kindler reaction triethylamine solvent; benzoxazolone acetyl Willgerodt Kindler reaction triethylamine solvent.Category: piperazines.

Yields in Willgerodt-Kindler reactions, e.g., of 4′-methoxyacetophenone with S8 and morpholine or of 6-acetyl-2(3H)-benzoxazolone with S8 and morpholine, piperidine, and piperazines, are improved when Et3N is used as the solvent.

In some applications, this compound(54903-09-2)Category: piperazines is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromopriopionaldehydediethylacetal(SMILESS: CC(Br)C(OCC)OCC,cas:3400-55-3) is researched.Electric Literature of C9H7NO3. The article 《Base-catalyzed dehydrobromination of several α-bromoacetals》 in relation to this compound, is published in Canadian Journal of Chemistry. Let’s take a look at the latest research on this compound (cas:3400-55-3).

Base-catalyzed dehydrohalogenation with tert-BuOK in tert-BuOH of the acetals obtained from homologs of α-bromoacetaldehyde and ethylene glycol[2-(α-bromoalkyl)-1,3-dioxolanes] or 1,3,-propanediol[2-(α-bromoalkyl)-1,3-dioxane] provides the corresponding ketene acetal, in some cases exclusively and in others as the major product along with a smaller proportion of the α,β-unsaturated acetal. In contrast, similar dehydrohalogenation conditions convert the acetals obtained from homologs of α-bromoacetaldehyde and monohydroxy alcs, to the α,β-unsaturated acetals, in some cases exclusively, and in others as the major product accompanied by a smaller proportion of the corresponding ketene acetal. The preference for the ketene acetal formation from the 2-(α-bromoalkyl)-1,3-dioxolanes (the ethylene acetals) is believed due to greater ease of approach by base to the methine proton as a result of the restricted shape of the 1,3-dioxolane ring. Approach by base to the methine proton of the α-bromoalkyl dialkylacetals is more hindered by the two alkoxy groups, which cause preferred attack by base at the β proton to provide the α,β-unsatd acetal. The proportion of α,β-unsaturated acetal obtained from base-catalyzed dehydrohalogenation of 2-(α-bromoalkyl)-1,3-dioxolanes can be greatly increased if the reaction is carried out in Me2SO. This marked change in proportion of products is thought to be due to a change in mechanism occasioned by the Me2SO.

In some applications, this compound(3400-55-3)Application In Synthesis of 2-Bromopriopionaldehydediethylacetal is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C9H7NO3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Design and synthesis of 3-acyl-2(3H)-benzoxazolone and 3-acyl-2(3H)-benzothiazolone derivatives.

An efficient “”green”” method for facile and rapid N-acylation of 2(3H)-benzoxazolones and 2(3H)-benzothiazolones by acyl chlorides using solid sodium hydroxide in a solvent mixture of acetone/water is reported. was found to catalyze N-acylation N-acyl derivatives This method was applied to the synthesis of a series of 132 compounds I (R1 = H, O2N, Br, etc.; R2 = Me, Et, Ph, etc.; X = O, S) in excellent yields.

In some applications, this compound(54903-09-2)Electric Literature of C9H7NO3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of 1,10-Phenanthroline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Tuning the coordination environment of single-atom catalyst M-N-C towards selective hydrogenation of functionalized nitroarenes. Author is Zhou, Dan; Zhang, Leilei; Liu, Xiaoyan; Qi, Haifeng; Liu, Qinggang; Yang, Ji; Su, Yang; Ma, Jingyuan; Yin, Jianzhong; Wang, Aiqin.

Fine-tuning of the coordination environment of single-atom catalysts (SACs) is effective to optimize their catalytic performances, yet it remains challenging due to the vulnerability of SACs. Herein, we report a new approach to engineering the coordination environment of M-N-C (M = Fe, Co, and Ni) SACs by using glutamic acid as the N/C source and pyrolysis atm. as a regulator. Compared with that in N2, NH3 was able to promote the doping of N at T < 700°C yet etch the N-species at higher temperatures, by which the M-N coordination number (CN) and the electronic structure were delicately tuned. It was found that the electron d. of Ni single atoms increased with the decrease of Ni-N CN. As a consequence, the capability of Ni-N-C to dissociate H2 was greatly enhanced and a higher catalytic activity in chemoselective hydrogenation of functionalized nitroarenes was achieved. Moreover, this modulation method could be applied to other transition metals including Fe and Co. In particular, the as-synthesized Co-N-C SAC afforded a turnover frequency of 152.3 h-1 with 99% selectivity to 3-vinylaniline in the hydrogenation of 3-nitrostyrene, which was the highest ever reported thus far and was at least one order of magnitude more active than state-of-the-art noble-metal-free M-N-C catalysts, demonstrating the great potential of engineering the coordination environment of SACs. In some applications, this compound(66-71-7)Application In Synthesis of 1,10-Phenanthroline is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Safety of Potassiumtris(1-pyrazolyl)borohydride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about Synthesis and Reactivity of Neutral and Cationic Ruthenium(II) Tris(pyrazolyl)borate Alkylidenes. Author is Sanford, Melanie S.; Henling, Lawrence M.; Grubbs, Robert H..

A series of neutral and cationic ruthenium(II) alkylidenes containing the hydrotris(pyrazolyl)borate (Tp) ligand have been prepared The complex Tp(PCy3)(Cl)Ru:CHPh (2) was obtained by the reaction of (PCy3)2(Cl)2Ru:CHPh with KTp. Treatment of 2 with AgBF4 or AgSbF6 in the presence of a variety of coordinating solvents afforded [Tp(PCy3)(L)Ru:CHPh]+ (L = H2O, CH3CN, pyridine) in high yield. The dynamic NMR behavior of these new complexes is discussed, and the x-ray crystal structure of [Tp(PCy3)(H2O)Ru:CHPh]BF4 (3) is reported. Alkylidenes 2-5 alone do not catalyze olefin metathesis reactions. However, complex 2 is activated for ring-closing metathesis by the addition of HCl, CuCl, and AlCl3.

In some applications, this compound(18583-60-3)Safety of Potassiumtris(1-pyrazolyl)borohydride is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Structural speciation in chemical reactivity profiling of binary-ternary systems of Ni(II) with iminodialcohol and aromatic chelators, the main research direction is preparation nickel iminodialc bipyridine phenanthroline complex reactivity luminescence dft.Reference of 1,10-Phenanthroline.

The importance of structural speciation in the control of chem. reactivity in Ni(II) binary-ternary systems, involving (O,O,N)-containing substrates (1,1′-iminodi-2-propanol), and aromatic chelators (2,2′-bipyridine, 1,10-phenanthroline), prompted the systematic synthesis of new crystalline materials characterized by elemental anal., FTIR, UV-Visible, Luminescence, magnetic susceptibility, and x-ray crystallog. The structures contain mononuclear octahedral assemblies, the lattice architecture of which exemplifies reaction conditions under which conformational variants and solvent-associated lattice-imposed complexes are assembled. Transformations between complex species denote their association with reactivity pathways, suggesting alternate synthetic methodologies for their isolation. Theor. work (Hirshfeld, Electrostatic Potential, DFT) signifies the impact of crystal structure on energy profiles of the generated species. The arisen physicochem. profiles of all compounds portray a well-configured interwoven network of pathways, projecting strong connection between structural speciation and Ni(II) reactivity patterns in organic-solvent media. The collective results provide well-defined parameterized profiles, poised to influence the synthesis of new Ni(II)-iminodialc. materials with specified structural-magneto-optical properties.

In some applications, this compound(66-71-7)Reference of 1,10-Phenanthroline is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Acetylbenzo[d]oxazol-2(3H)-one, is researched, Molecular C9H7NO3, CAS is 54903-09-2, about Synthesis of chalcones condensed with an 1,3-azole ring using a SOCl2/EtOH catalytic system.Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one.

A series of substituted heterocyclic chalcones were synthesized by aldol condensation of corresponding heterocyclic ketones (preparation shown) aromatic aldehydes, in the presence of thionyl chloride-EtOH as a catalyst. The reaction was stereoselective and only trans-isomers were obtained in excellent yields and purity. Three out of 7 prepared chalcones (I, R = H, OH, OMe) were tested in vitro for their antitumor activity. They were found to have IC50 values ranging between 10-15 μM.

In some applications, this compound(54903-09-2)Recommanded Product: 6-Acetylbenzo[d]oxazol-2(3H)-one is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics