Month: April 2022

HPLC of Formula: 97966-01-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,3-Dichloro-5-iodopyridine, is researched, Molecular C5H2Cl2IN, CAS is 97966-01-3, about Synthesis of 2, 3-dichloro-5-iodopyridine. Author is Chai, Huifang; Zeng, Xiaoping; Teng, Minggang; Duan, Lian.

In the paper, we introduced a approach to synthesize the title compound, was realized and manufactured from 2, 3-dichloropyridine via four steps. Its structure was verified by MS and 1H NMR. This synthetic route has the advantages of convenient operation and mild reaction conditions. The total product yield was 51%. This program is suitable for industrial production

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,10-Phenanthroline(SMILESS: C1=CC3=C(C2=NC=CC=C12)N=CC=C3,cas:66-71-7) is researched.Computed Properties of C5H10O3. The article 《Intelligent graphene oxide membranes with pH tunable channels for water treatment》 in relation to this compound, is published in Chemical Engineering Journal (Amsterdam, Netherlands). Let’s take a look at the latest research on this compound (cas:66-71-7).

Adaptive membranes that can intelligently control their permeability or selectivity depending on the surrounding environments are of extraordinary importance in the separation technol. area. Herein, we report the pH responsive membranes through covalently grafting weak Polyelectrolytes (poly(acrylic acid) (PAA) or poly(4-vinylpyridine) (P4VP)) onto the regular two dimensional (2D) channels stacked by Graphene oxide (GO) nanosheets. Attributed to the reversible shrinking/stretching function of PAA (or P4VP) chains with the variation of external pH, the switchable 2D GO channels are thus established successfully. Correspondingly, the resulting PAA@GO and P4VP@GO 2D membranes show promising nano-gating ratios of ∼ 5 accompanied by satisfactory water permeances. Furthermore, the pH responsive 2D channels render these two types of membranes with the adaptive ability of rejecting different sized species according to separation requirements. For disposing industrial alk. (or acid) effluents, PAA@GO (or P4VP@GO) membranes exhibit outstanding alk. (or acid) recovery performance as well.

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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-Methyl 3-hydroxybutanoate, is researched, Molecular C5H10O3, CAS is 53562-86-0, about Enantio-differentiating hydrogenation of methyl acetoacetate over modified Raney nickel catalysts prepared by two-step modifications.Computed Properties of C5H10O3.

Two-step modifications of Raney nickel were examined for the enantio-differentiating hydrogenation of Me acetoacetate. The combination of pre-modification with disodium tartrate and NaBr in water and in-situ modification with tartaric acid resulted in the highest optical yield (84%) of hydrogenation product. This modification process is greener [environmentally benign] process than conventional modification carried out under weakly acidic conditions, because this process generated almost no Ni2+ ions. The pre-modification with tartrate and NaBr preferentially eliminated Al3+ from Raney nickel surface.

Although many compounds look similar to this compound(53562-86-0)Computed Properties of C5H10O3, numerous studies have shown that this compound(SMILES:C[C@H](O)CC(OC)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C9H10BKN6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Potassiumtris(1-pyrazolyl)borohydride, is researched, Molecular C9H10BKN6, CAS is 18583-60-3, about Linkage isomerism in a face-centered cubic Cu6Cr8(CN)24 cluster with an S = 15 ground state. Author is Harris, T. David; Long, Jeffrey R..

Access to [TpCr(CN)3]- (Tp = hydrotris(pyrazol-1-yl)borate) enables isolation of two metastable linkage isomers of a fcc. cluster, [Tp8(H2O)6Cu6Cr8(CN)24]4+, both exhibiting an S = 15 ground state. X-ray crystal structures of precursor (Bu4N)[TpCr(CN)3], of [Tp8(H2O)6Cu6Cr8(CN)24](ClO4)4 with partially isomerized bridging cyano ligands (Cr-CN-Cu and Cr-NC-Cu), and of the cluster with only Cr-CN-Cu linkages are presented.

Although many compounds look similar to this compound(18583-60-3)Electric Literature of C9H10BKN6, numerous studies have shown that this compound(SMILES:[BH-](N1N=CC=C1)(N2N=CC=C2)N3N=CC=C3.[K+]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Homo- and heterometallic oxalate-based complexes obtained using [Cr(C2O4)3]3- building block – Two polymorphs of a solvate, published in 2022-01-01, which mentions a compound: 66-71-7, Name is 1,10-Phenanthroline, Molecular C12H8N2, Safety of 1,10-Phenanthroline.

Two heterometallic complex salts, as polymorphs of a solvate, consisting of three different mononuclear units, [CuCl(phen)2][Cu(H2O)(phen)2][Cr(C2O4)3]·nH2O [n = 5 (1) and n = 8 (2); phen = 1,10-phenanthroline] were obtained in reactions in which [Cr(C2O4)3]3- was used as a building unit. The polymorphs of a solvate are obtained in crystalline forms that differ in type or stoichiometry of included solvent mols., mostly obtained under different conditions. In this [CuIICrIII] system, the used solvents and crystallization method influence the final product, i.e., the formation of a specific solvatomorph. From the reaction of an aqueous solution of K3[Cr(C2O4)3]·3H2O and acetonitrile solutions containing phen and CuCl2·2H2O, compound 1 was formed when the layering technique is used; and compound 2 can be obtained from the mixture of these reactants, but using methanol instead of acetonitrile. Based on the index parameter for the degree of trigonality, τ, the geometry of copper(II) atoms of the [Cu(H2O)(phen)2]2+ cations in 1 and 2 are distorted from square pyramidal toward trigonal bipyramidal conformation, while those of [CuCl(phen)2]+ have a trigonal bipyramidal geometry. Interestingly, in the presence of [NBu4]+ cations, and applying slow liquid diffusion, partial decomposition of the building block [Cr(C2O4)3]3- occurred and the homobinuclear oxalate-bridged complex [{Cu(bpy)Cl}2(μ-C2O4)]·CH3OH (3; bpy = 2,2′-bipyridine) was formed. Consequently, the oxalate ligand released from the coordination sphere of CrIII was coordinated to CuII ions during the crystallization process. The obtained oxalate-based compounds 1-3 were characterized by IR spectroscopy and single-crystal x-ray diffraction.

Although many compounds look similar to this compound(66-71-7)Safety of 1,10-Phenanthroline, numerous studies have shown that this compound(SMILES:C1=CC3=C(C2=NC=CC=C12)N=CC=C3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Related Products of 66-71-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Synthesis, characterisation and biological activity of the ruthenium(II) complexes of the N4-tetradentate (N4-TL), 1,6-di(2′-pyridyl)-2,5-dibenzyl-2,5-diazahexane (picenBz2). Author is Bjelosevic, Aleksandra; Sakoff, Jennette; Gilbert, Jayne; Zhang, Yingjie; McGhie, Brondwyn; Gordon, Christopher; Aldrich-Wright, Janice R..

A series of complexes of the type rac-cis-β-[Ru(N4-TL)(N2-bidentates)]2+ (N4-TL = 1,6-di(2′-pyridyl)-2,5-dibenzyl-2,5-diazahexane) (picenBz2, N4-TL-2) and N2-bidentates = 1,10-phenanthroline (phen, Ru-2), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq, Ru-3), 7,8-dimethyl-dipyrido[3,2-a:2′,3′-c] phenazine (dppzMe2, Ru-4), 2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline (phenpyrBz, Ru-5), 2-(p-tolyl)-1H-imidazo[4,5-f][1,10]phenanthroline (phenpyrBzMe, Ru-6), 2-(4-nitrophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline (phenpyrBzNO2, Ru-7), were synthesized and characterized and x-ray crystallog. of Ru-5 obtained. The in vitro cytotoxicity assays revealed that Ru-6 was 5, 2 and 19-fold more potent than oxaliplatin, cisplatin, and carboplatin, resp. displaying an average GI50 value of ≈ 0.76 μM against a panel of 11 cancer cell lines.

Although many compounds look similar to this compound(66-71-7)Related Products of 66-71-7, numerous studies have shown that this compound(SMILES:C1=CC3=C(C2=NC=CC=C12)N=CC=C3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Enzyme Inhibition and Medicinal Chemistry called Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents, Author is Veschi, Serena; Carradori, Simone; De Lellis, Laura; Florio, Rosalba; Brocco, Davide; Secci, Daniela; Guglielmi, Paolo; Spano, Mattia; Sobolev, Anatoly P.; Cama, Alessandro, which mentions a compound: 16004-15-2, SMILESS is IC1=CC=C(CBr)C=C1, Molecular C7H6BrI, Quality Control of 1-(Bromomethyl)-4-iodobenzene.

Pancreatic cancer (PC) is one of the deadliest carcinomas and in most cases, which are diagnosed with locally advanced or metastatic disease, current therapeutic options are highly unsatisfactory. Based on the anti-proliferative effects shown by nitroxoline, an old urinary antibacterial agent, we explored a large library of newly synthesized derivatives to unravel the importance of the OH moiety and pyridine ring of the parent compound The new derivatives showed a valuable anti-proliferative effect and some displayed a greater effect as compared to nitroxoline against three pancreatic cancer cell lines with different genetic profiles. In particular, in silico pharmacokinetic data, clonogenicity assays and selectivity indexes of the most promising compounds showed several advantages for such derivatives, as compared to nitroxoline. Moreover, some of these novel compounds had stronger effects on cell viability and/or clonogenic capacity in PC cells as compared to erlotinib, a targeted agent approved for PC treatment.

Although many compounds look similar to this compound(16004-15-2)Quality Control of 1-(Bromomethyl)-4-iodobenzene, numerous studies have shown that this compound(SMILES:IC1=CC=C(CBr)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Harada, Tadao; Imachi, Yoshimi; Tai, Akira; Izumi, Yoshiharu published the article 《Modification of nickel surface with optically active substrate: the method and mechanism》. Keywords: tartaric acid modification reduced nickel; enantioface differentiating nickel catalyst; stereochem reduction acetoacetate nickel catalyst; hydroxybutyrate; asym induction hydrogenation acetoacetate.They researched the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ).Recommanded Product: (S)-Methyl 3-hydroxybutanoate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:53562-86-0) here.

The enantioface-differentiating ability (e.d.a.) of tartaric acid (I) modified reduced Ni catalysts, examined in the reduction of AcCH2CO2Me to MeCH(OH)CH2CO2Me, was strongly affected by the type of NiO used for catalyst preparation and the preparative treatment. Acidic and high temperature modification or acid-treatment of reduced Ni (HNi) before I modification improved to e.d.a. as these treatments removed the amorphous, nonstereodifferentiating, parts of the HNi.

Although many compounds look similar to this compound(53562-86-0)Recommanded Product: (S)-Methyl 3-hydroxybutanoate, numerous studies have shown that this compound(SMILES:C[C@H](O)CC(OC)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Al-Janabi, Emaad M. A.; Hatshan, Mohammad R.; Adil, Syed Farooq; Kadhum, Wesam R.; Al-Jibori, Subhi A.; Faihan, Ahmed S.; Al-Janabi, Ahmed S. published the article 《Spectroscopic, antibacterial and anti-cancer studies of new platinum(II)-diethyldithiocarbamate mixed ligand complexes with phosphine or amine ligands》. Keywords: platinum diethyldithiocarbamate phosphine amine complex preparation antibacterial antitumor activity.They researched the compound: 1,10-Phenanthroline( cas:66-71-7 ).Computed Properties of C12H8N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:66-71-7) here.

A series of new platinum(II) mixed ligand complexes of diethyldithiocarbamate (Et2DT) and phosphine or amine ligands of the type [Pt(Et2DT)2(diphosphine)] (3-6), [Pt(Et2DT)2(diamine)](7-8), [Pt(Et2DT)2(PPh3)2] (9) and [Pt(Et2DT)2(SPPh3)2](10) have been prepared in good yield and fully characterized by elemental anal., conductivity measurements and spectroscopic data (i.r., 1H, 31P-{1H} nmr). Our interest in these types of complexes are based on the fact that these complexes are known for their promising biol. activity, and could possess interesting coordination modes, which are poorly represented in the literature. Therefore, the prepared complexes were tested for their anti-bacterial against three types of pathogenic bacteria namely S. aureus, E. coli, and p. aeruginosa. In addition, four of the prepared complexes were screened for their anti-cancer activity against lung cancer cell lines, and that the [Pt(Et2DT)2(bipy)] was significantly more potent with IC50 value is 1.0 ± 0.2μM, but the [Pt(Et2DT)2(dppf)] was practically inactive in the selected dose range with IC50 value is 32.0 ± 3.0μM.

Although many compounds look similar to this compound(66-71-7)Computed Properties of C12H8N2, numerous studies have shown that this compound(SMILES:C1=CC3=C(C2=NC=CC=C12)N=CC=C3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Formula: C8H8FN. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Rh(III)-Catalyzed C7-Thiolation and Selenation of Indolines. Author is Xie, Wucheng; Li, Bin; Wang, Baiquan.

The rhodium(III)-catalyzed intermol. C7-thiolation and selenation of indolines with disulfides and diselenides were developed. This protocol relies on the use of a removable pyrimidyl directing group to access valuable C-7 functionalized indoline scaffolds with ample substrate scope and broad functional group tolerance.

Although many compounds look similar to this compound(2343-22-8)Formula: C8H8FN, numerous studies have shown that this compound(SMILES:FC1=CC2=C(NCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics