Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Phenanthroline-based Ni(II) coordination compounds involving unconventional discrete fumarate-water-nitrate clusters and energetically significant cooperative ternary π-stacked assemblies: Antiproliferative evaluation and theoretical studies.Name: 1,10-Phenanthroline.
Two new Ni(II) coordination complexes involving fumarate and 1,10-phenanthroline viz.; [Ni2(phen)2(μ-fum)(H2O)6](fum)·6H2O (1) and [Ni(phen)2(H2O)2](0.5 fum)(NO3)·4H2O (2) (fum = fumarate, phen = 1,10-phenanthroline) were isolated in aqueous medium at room temperature Crystal structure analyses of the compounds reveal cooperative (π-π)2/(π-π)1/(π-π)2 stacked ternary assemblies which provide stabilities to the layered architectures. The lattice water and the large counteranions in the lattice of the compounds are involved in the formation of unconventional discrete cyclic fumarate-water, fumarate-water-nitrate clusters and infinite nitrate-water 1D chains that are very scarcely reported in the literature. The energetically significant π-stacked dimers observed in the biol. relevant ternary assemblies of the crystal structures were further studied theor. using DFT calculations and NCI plot index computational tools. DFT calculations reveal that the cooperative (π-π)2 binding mode of 1 is energetically more significant than (π-π)1 Moreover, the study also reveals that for the equivalent cooperative (π-π)1 stacking interactions in both the structures, the energy is unexpectedly higher for 2 than that observed for 1. Both the compounds induce significant cytotoxicity in Da’s lymphoma (DL) cancer cells by inducing apoptotic cell death with negligible cytotoxicity in normal cells. Decrease in the mitochondrial membrane potential (MMP) of DL cells after treatment with the compounds also corroborates the apoptotic cell death. The mol. docking and pharmacophore features reveal that the compounds interact and accommodated well with the active sites of anti-apoptotic proteins.
Although many compounds look similar to this compound(66-71-7)Name: 1,10-Phenanthroline, numerous studies have shown that this compound(SMILES:C1=CC3=C(C2=NC=CC=C12)N=CC=C3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics