Related Products of 66-71-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Synthesis, characterisation and biological activity of the ruthenium(II) complexes of the N4-tetradentate (N4-TL), 1,6-di(2′-pyridyl)-2,5-dibenzyl-2,5-diazahexane (picenBz2). Author is Bjelosevic, Aleksandra; Sakoff, Jennette; Gilbert, Jayne; Zhang, Yingjie; McGhie, Brondwyn; Gordon, Christopher; Aldrich-Wright, Janice R..
A series of complexes of the type rac-cis-β-[Ru(N4-TL)(N2-bidentates)]2+ (N4-TL = 1,6-di(2′-pyridyl)-2,5-dibenzyl-2,5-diazahexane) (picenBz2, N4-TL-2) and N2-bidentates = 1,10-phenanthroline (phen, Ru-2), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq, Ru-3), 7,8-dimethyl-dipyrido[3,2-a:2′,3′-c] phenazine (dppzMe2, Ru-4), 2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline (phenpyrBz, Ru-5), 2-(p-tolyl)-1H-imidazo[4,5-f][1,10]phenanthroline (phenpyrBzMe, Ru-6), 2-(4-nitrophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline (phenpyrBzNO2, Ru-7), were synthesized and characterized and x-ray crystallog. of Ru-5 obtained. The in vitro cytotoxicity assays revealed that Ru-6 was 5, 2 and 19-fold more potent than oxaliplatin, cisplatin, and carboplatin, resp. displaying an average GI50 value of ≈ 0.76 μM against a panel of 11 cancer cell lines.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics