The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Fluoroindoline(SMILESS: FC1=CC2=C(NCC2)C=C1,cas:2343-22-8) is researched.Product Details of 53636-17-2. The article 《Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Optimization of P1 and N-aryl》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:2343-22-8).
A systematic study of anilines led to the discovery of a metabolically robust fluoroindoline replacement for the alkoxy aniline toxicophore in 1. Investigations of the P1 pocket resulted in the discovery of a wide tolerance of functionality leading to the discovery of 11 as a potent and selective inhibitor of cathepsin S.
Compounds in my other articles are similar to this one(5-Fluoroindoline)Recommanded Product: 2343-22-8, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics