Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 54903-09-2, is researched, Molecular C9H7NO3, about A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide, the main research direction is photoacoustic probe imaging nitric oxide.Product Details of 54903-09-2.
Photoacoustic (PA) imaging is an emerging, hybrid imaging modality that uses optical excitation and acoustic detection to enable high resolution at centimeter depths. The development of activatable PA probes can allow for detection of specific stimuli within a variety of live-animal models using this technol. Herein, the authors report the design, development, and evaluation of a series of Acoustogenic Probe(s) for Nitric Oxide (APNO) for the ratiometric, analyte-specific detection of nitric oxide (NO) in vivo. The best probe in this series, APNO-5 (I), responds rapidly to NO to form an N-nitrosylated product that exhibits an absorbance maximum that is 91 nm blue-shifted relative to the probe. This property enables ratiometric PA imaging upon selective irradiation of APNO-5 and the corresponding product. Moreover, APNO-5 displays the requisite photophys. characteristics for in vivo PA imaging (e.g., high absorptivity, low quantum yield) as well as high biocompatibility, stability, and selectivity for NO over a variety of biol. relevant analytes. APNO-5 was successfully applied to the detection of endogenous NO in a murine lipopolysaccharide-induced inflammation model at depths up to 2.5 cm. The authors’ studies show a 1.9-fold increase in PA signal at 680 nm and a 1.3-fold ratiometric turn-on relative to a saline control.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics