The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Fluoroindoline(SMILESS: FC1=CC2=C(NCC2)C=C1,cas:2343-22-8) is researched.Quality Control of 1,10-Phenanthroline. The article 《Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors》 in relation to this compound, is published in ACS Chemical Neuroscience. Let’s take a look at the latest research on this compound (cas:2343-22-8).
Activation of HIF-1α and Nrf2 is a primary component of cellular response to oxidative stress, and activation of HIF-1α and Nrf2 provides neuroprotection in models of neurodegenerative disorders, including ischemic stroke, Alzheimer’s and Parkinson’s diseases. Screening a library of CNS-targeted drugs using novel reporters for HIF-1α and Nrf2 elevation in neuronal cells revealed histone deacetylase (HDAC) inhibitors as potential activators of these pathways. We report the identification of phenylhydroxamates as single agents exhibiting tripartite inhibition of HDAC6, inhibition of HIF-1 prolyl hydroxylase (PHD), and activation of Nrf2. Two superior tripartite agents, ING-6 and ING-66, showed neuroprotection against various cellular insults, associated with stabilization of both Nrf2 and HIF-1, and expression of their resp. target genes in vitro and in vivo. Discovery of the innate ability of phenylhydroxamate HDAC inhibitors to activate Nrf2 and HIF provides a novel route to multifunctional neuroprotective agents and cautions against HDAC6 selective inhibitors as chem. probes of specific HDAC isoform function.
This literature about this compound(2343-22-8)Synthetic Route of C8H8FNhas given us a lot of inspiration, and I hope that the research on this compound(5-Fluoroindoline) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics