So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Preobrazhenskaya, M. N.; Mukhanov, V. I.; Kostyuchenko, N. P.; Suvorov, N. N. researched the compound: 5-Fluoroindoline( cas:2343-22-8 ).SDS of cas: 2343-22-8.They published the article 《Glycosylindoles. XI. Synthesis of 1-β-D-ribopyranosides of 5- and 6-fluoroindole》 about this compound( cas:2343-22-8 ) in Zhurnal Organicheskoi Khimii. Keywords: ribopyranosylindole fluoro; conformation ribopyranoside indole. We’ll tell you more about this compound (cas:2343-22-8).
Treatment of 6-fluoroindoline with D-ribose, followed by acetylation gave 72% 6-fluoro derivative (I; R = Ac, X = 6-F) which was dehydrogenated by heating with 2,3-dichloro-5,6-dicyanoquinone to give 44% of the indole derivative (II; R = Ac, X = 6-F). Deacetylation of the latter with Na-OMe-MeOH gave 97% 1-β-D-ribopyranosyl-6-fluoroindole (II; R = H, X = 6-F). Analogously prepared were the 5-fluoro derivatives and the corresponding α-D-anomers. Conformations of the ribopyranosyl group were determined by PMR.
In addition to the literature in the link below, there is a lot of literature about this compound(5-Fluoroindoline)SDS of cas: 2343-22-8, illustrating the importance and wide applicability of this compound(2343-22-8).
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics