Computed Properties of C8H8FN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about 5-Hydroxytryptamine (5-HT3) receptor antagonists. 2. 1-Indolinecarboxamides. Author is Bermudez, Jose; Dabbs, Steven; Joiner, Karen A.; King, Frank D..
Indazole I is a potent and selective 5-HT3 receptor antagonist. A novel series of potent 5-HT3 receptor antagonists, 1-indoline- and 1-indolecarboxamides II [R = H , F, Cl, MeO, O2N; R1 = H, Me, Et, Ph; R2 = H, Me; R1R2 = (CH2)2, (CH2)4, (CH2)5; R3 = H, Me; n = 2,3] and III (R1 = H, Me, Et, Ph), resp., is described. The activity of II suggests that aromaticity of the 5-membered ring is not an essential requirement for potency provided that an in plane orientation of the CO group is favored. On the basis of this hypothesis indene IV was prepared In IV the in plane orientation of the CO group is maintained by conjugation with the aromatic ring through the sp2-hybridized C. IV is also a potent 5-HT3 receptor antagonist.
In addition to the literature in the link below, there is a lot of literature about this compound(5-Fluoroindoline)Computed Properties of C8H8FN, illustrating the importance and wide applicability of this compound(2343-22-8).
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics