Synthetic Route of C8H8FN. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Novel purine conjugates with N-heterocycles: synthesis and anti-influenza activity. Author is Krasnov, Victor P.; Zarubaev, Vladimir V.; Gruzdev, Dmitry A.; Vozdvizhenskaya, Olga A.; Vakarov, Sergey A.; Musiyak, Vera V.; Chulakov, Evgeny N.; Volobueva, Alexandrina S.; Sinegubova, Ekaterina O.; Ezhikova, Marina A.; Kodess, Mikhail I.; Levit, Galina L.; Charushin, Valery N..
A number of novel amides were synthesized by coupling of 6-[(9H-purin-6-yl)amino]hexanoic acid to heterocyclic amines. The antiviral activity of the obtained compounds, as well as of purine conjugates in which 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine is linked to position 6 of purine through a fragment of ω-amino acids with varying lengths of polymethylene chains against influenza A and B viruses was studied in vitro. Purine derivatives showed to have moderate activity against influenza A (H1N1) virus. The antiinfluenza activity and cytotoxicity of conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine depend on the length of the linker fragment.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics