Formula: C8H8FN. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Oxidative Palladium(II)-Catalyzed C-7 Alkenylation of Indolines. Author is Jiao, Lin-Yu; Oestreich, Martin.
N-(dimethylcarbamoyl)indolines such as I underwent regioselective and stereoselective alkenylation with electron-deficient alkenes and styrenes RR1C:CHR2 [R = BuO2C, MeO2C, EtO2C, PhCH2O2C, MeCO, NC, (EtO)2P(:O), Ph, F5C6, 4-FC6H4, 4-ClC6H4, 2-ClC6H4, 2-BrC6H4; R1, R2 = H, Me] with 1,4-benzoquinone in acetic acid in the presence of Pd(OAc)2 and p-toluenesulfonic acid to give (E)-7-alkenylindolinecarboxamides such as II in 21-89% yield and all except II (R = MeO2C; R1 = H; R2 = Me) as the (E)-isomers in >98:2 dr. The tetrasubstituted urea moiety functioned as a directing group for directed alkenylation; non-urea directing groups either yielded alkenylation products in low (20%) yield or did not yield alkenylation products. An ethylcarbamoylindoline underwent alkenylation with Bu acrylate followed by cyclization to give oxoindolopyrimidineacetate III.
Compound(2343-22-8)Formula: C8H8FN received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Fluoroindoline), if you are interested, you can check out my other related articles.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics