The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Iodo-1H-indazol-5-amine, is researched, Molecular C7H6IN3, CAS is 599183-36-5, about 2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization, the main research direction is diaminopyrimidine MK2 inhibitor preparation structure inhibitor.Related Products of 599183-36-5.
We describe structure-based optimization of a series of novel 2,4-diaminopyrimidine MK2 inhibitors. Co-crystal structures (see accompanying Letter) demonstrated a unique inhibitor binding mode. Resulting inhibitors had IC50 values as low as 19 nM and moderate selectivity against a kinase panel. Compounds 15, 31a, and 31b inhibit TNFα production in peripheral human monocytes.
Compound(599183-36-5)Related Products of 599183-36-5 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(3-Iodo-1H-indazol-5-amine), if you are interested, you can check out my other related articles.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics