The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The configurational relationships between α hydroxy acids and β-hydroxy acids and between the latter and secondary alcohols》. Authors are Levene, P. A.; Haller, H. L..The article about the compound:(S)-Methyl 3-hydroxybutanoatecas:53562-86-0,SMILESS:C[C@H](O)CC(OC)=O).Name: (S)-Methyl 3-hydroxybutanoate. Through the article, more information about this compound (cas:53562-86-0) is conveyed.
It is proposed to study the relation between β-HO acids, α-HO acids and the secondary alcs. by means of the reactions RCH(OH)CH2CO2Et → RCH(OH)CH2NH2 → RCH(OH)CH2OH → RCH(OH)CO2H; RCH(OH)CH2NH2 → RCH(OH)CH2Cl → RCH(OH)CH2CH2CO2H → RCH(OH)Et; RCH(OH)CH2Cl → RCH(OH)Me. Levo-3-hydroxybutyric acid (J. Chem. Soc. 81, 1402(1902)) [α]D25 -24.5°, in H2O. Me Levo-3-hydroxybutyrate (cf. Fischer and Scheibler, C. A. 3, 2135), b17 70-2°, [α]D20 -20.9°, without solvent. Levo-3-hydroxybutyrylhydrazide, C4H10O2N2, m. 129-30°, [α]D31 -29.3°, in EtOH. sym-Dextro-2-hydroxypropylurea, C7H16O3N2, [α]D26.5 18.5°. Levo-2-hydroxypropylamine-HCl, C3H10ONCl, [α]D26.5 -31.2° in H2O, much less in N NaOH, (the last 3 substances were prepared according to methods of Levene and Scheidegger, C. A. 19, 1128, for inactive compounds). Levo-1,2-dihydroxypropane, from the amine, AgNO2 and HCl.
Compound(53562-86-0)Name: (S)-Methyl 3-hydroxybutanoate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((S)-Methyl 3-hydroxybutanoate), if you are interested, you can check out my other related articles.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics