In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Microwave-Assisted Tandem Kornblum Oxidation and Biginelli Reaction for the Synthesis of Dihydropyrimidones, published in 2020-10-19, which mentions a compound: 16004-15-2, mainly applied to dihydropyrimidone dihydro pyrimidinethione preparation green chem microwave irradiation; urea aralkyl bromide ethyl acetoacetate tandem Kornblum Biginelli cyclocondensation; thiourea aralkyl bromide ethyl acetoacetate tandem Kornblum Biginelli cyclocondensation, HPLC of Formula: 16004-15-2.
A simple and straightforward approach for the synthesis of dihydropyrimidones I (X = O, S; Ar = Ph, 4-FC6H4, pyridin-2-yl, 1H-pyrrol-2-yl, etc.) via sequential Kornblum oxidation/Biginelli reaction has been developed. The protocol involves an in situ oxidation of benzyl bromides ArCH2Br which serve as a carbonyl equivalent followed by cyclocondensation with (thio)urea and Et acetoacetate to furnish dihydropyrimidones I under catalyst- and base-free conditions in a one-pot tandem manner under microwave irradiation Further, the product purification using aqueous recrystallization avoids large quantities of volatile and a toxic organic solvent usually required for work-up and significantly less time required for this process makes the method environmentally friendly.
Compound(16004-15-2)HPLC of Formula: 16004-15-2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Bromomethyl)-4-iodobenzene), if you are interested, you can check out my other related articles.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics