Cohrt, A. Emil; Nielsen, Thomas E. published the article 《Solid-Phase Synthesis of Peptide Thioureas and Thiazole-Containing Macrocycles through Ru-Catalyzed Ring-Closing Metathesis》. Keywords: peptide thiourea solid phase preparation; guanidino peptide solid phase preparation; thiazole macrocycle peptide solid phase preparation ring closing metathesis.They researched the compound: 2-Bromopriopionaldehydediethylacetal( cas:3400-55-3 ).Formula: C7H15BrO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3400-55-3) here.
N-Terminally modified α-thiourea peptides can selectively be synthesized on solid support under mild reaction conditions using N,N’-di-Boc-thiourea and Mukaiyama’s reagent (2-chloro-1-methyl-pyridinium iodide). This N-terminal modification applies to the 20 proteinogenic amino acid residues on three commonly used resins for solid-phase synthesis. Complementary methods for the synthesis of α-guanidino peptides have also been developed. The thiourea products underwent quant. reactions with α-halo ketones to form thiazoles in excellent purities and yields. When strategically installed between two alkene moieties, said thiazole core was conveniently embedded in peptide macrocycles via Ru-catalyzed ring-closing metathesis reactions. Various 15-17 membered macrocycles were easily accessible in all diastereomeric forms using this methodol. The developed “”build/couple/pair”” strategy is well suited for the generation of larger and stereochem. complete screening libraries of thiazole-containing peptide macrocycles.
In some applications, this compound(3400-55-3)Formula: C7H15BrO2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics