The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Bromomethyl)-4-iodobenzene( cas:16004-15-2 ) is researched.Synthetic Route of C7H6BrI.Yang, Ren-Yin; Gao, Xinyan; Gong, Kehao; Wang, Juan; Zeng, Xiaojun; Wang, Mingwei; Han, Junbin; Xu, Bo published the article 《Synthesis of ArCF2X and [18F]Ar-CF3 via Cleavage of the Trifluoromethylsulfonyl Group》 about this compound( cas:16004-15-2 ) in Organic Letters. Keywords: aryldifluoromethylene compound preparation. Let’s learn more about this compound (cas:16004-15-2).
A versatile synthesis of ArCF2X and [18F]Ar-CF3 type compounds from readily available ArCF2SO2CF3 has been developed. Diverse nucleophiles, including weak nucleophiles such as halides (18F-, Cl-, Br-, and I-), RSH, and ROH, could react with ArCF2SO2CF3 efficiently to give the corresponding difluoromethylene products. The control experiments and the Hammett plot indicated that the reaction might proceed through a difluorocarbocation intermediate generated from the steric hindrance-assisted cleavage of the trifluoromethylsulfonyl group.
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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics