COA of Formula: C8H8FN. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Fluoroindoline, is researched, Molecular C8H8FN, CAS is 2343-22-8, about Synthesis and cytotoxicity evaluation of novel 5-fluorinated indoles. Author is Budovska, Mariana; Krochtova, Kristina; Kuba, Miroslav; Tischlerova, Viera; Mojzis, Jan.
Authors report herein the synthesis of a small 28-membered library of novel 5-fluorinated indole phytoalexins. Target compounds were designed by a structure-based bioisosterism strategy. The newly prepared compounds were screened in vitro for cytotoxic activity against seven human cancer cell lines. The cytotoxic evaluation revealed that the 2′-(3,4-dichlorophenylamino) analog of 5-fluorospirobrassinin was the most active against cancer cell lines without causing toxicity to HUVEC cells. Overall, 5-fluoro analogs of indole phytoalexins did not show improved anti-cancer activity compared to the lead compounds The preliminary structure-activity relationship (SAR) study revealed that placing fluoro substituent at C-5 position of the indole ring is not crucial for inducing cytotoxicity against a cancer cell line.
As far as I know, this compound(2343-22-8)COA of Formula: C8H8FN can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics