The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《An improved rhodium-DIOP catalyst system for the homogeneous asymmetric hydrogenation of acetophenone》. Authors are Chan, Albert S. C.; Landis, Clark R..The article about the compound:(S)-1-(Dimethylamino)propan-2-olcas:53636-17-2,SMILESS:C[C@H](O)CN(C)C).Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol. Through the article, more information about this compound (cas:53636-17-2) is conveyed.
Optical yields as high as 79% were obtained in the title reaction when a rhodium-DIOP-chloride catalyst system containing a tertiary hydroxyalkylamine promoter was used. The various factors governing the rates and selectivities are discussed.
As far as I know, this compound(53636-17-2)Application In Synthesis of (S)-1-(Dimethylamino)propan-2-ol can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics