So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hirose, Akane; Maeda, Hayato; Tonouchi, Akio; Nehira, Tatsuo; Hashimoto, Masaru researched the compound: (S)-Methyl 3-hydroxybutanoate( cas:53562-86-0 ).Application of 53562-86-0.They published the article 《Neomacrophorin I, II, and III, novel drimenyl cyclohexanes with hydroxylated butanoates from Trichoderma sp. 1212-03》 about this compound( cas:53562-86-0 ) in Tetrahedron. Keywords: neomacrophorin Trichoderma. We’ll tell you more about this compound (cas:53562-86-0).
Neomacrophorins I (1), II (2), and III (3) were isolated from the culture broth of Trichoderma sp. 1212-03 that was collected at Shirakami Mountainous area in Japan. Structural analyses disclosed that these resemble known macrophorins but possess axial-hydroxy group at C3 as well as different side chains at C7′. These are diastereomeric forms of macrophorins for 5′,6′-epoxide functionality. The NMR analyses suggested their relative configurational relationship between the C1-C15 drimene and C1′-C7′ epoxyquinone moieties. ECD spectral discussions verified them particularly for C5′,C6′-epoxyquinone (1), C5′,C6′-epoxysemiquinone (2 and 3), and 2″”,3″”-dihydroxybutanoate moiety in 1 and 2. The configuration of C3″”-stereocenter of 3 was determined by chiral GC-MS after converting into Me (S)-3″”-hydroxybutanoate by basic of 3 methanolysis. Biol. assays disclosed that 1 induces hyphal branching of Cochliobolus miyabeanus as well as cytotoxicity against human colorectal cancer COLO 201.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics