Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Synthesis called Tryptophan N1-alkylation: Quick and simple access to diversely substituted tryptophans, Author is Junk, Lukas; Papadopoulos, Emanuel; Kazmaier, Uli, which mentions a compound: 16004-15-2, SMILESS is IC1=CC=C(CBr)C=C1, Molecular C7H6BrI, Category: piperazines.
The diversification of amino acid sidechains is a major challenge in the synthesis and derivatization of peptides for pharmaceutical applications. We herein present a new protocol to alkylate the indole-nitrogen (N1) of Nα-protected tryptophans. This method provides quick and epimerization-free access to tryptophan derivatives, which can directly be incorporated into peptides. Depending on the functionalities introduced in the side chain, different options for the late-stage modification of peptides are possible.
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Reference:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics