With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.
[00239] Anhydrous DMSO (4.0 mL) was added to a pressure tube charged with the above sulfone (253 mg, 0.702 mmol) and 4-(4-ethylpiperazin-l-yl)phenylamine (159 mg, 0.773 mmol). The pressure tube was sealed and heated to 100 C. After 12 hours, the reaction was cooled to room temperature and poured into water (100 mL) and diluted with ethyl acetate (100 mL). The aqueous phase was separated and washed with an additional amount of ethyl acetate (100 mL). The organic layers were pooled, washed with brine, and dried over Na2SO4, filtered and concentrated in vacuo to afford 6-bromo-2-(4-(4-ethylpiperazin-l- yl)phenylamino)-4-methyl-8-(l-methylethyl)pyrido[2,3-115619-01-7, As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.
Reference：
Patent; EXELIXIS, INC.; WO2007/44698; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics