With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.373608-48-1,tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
A mincrowave vial was charged with DMAP (84 mg, 0.69 minol), Pd(OAc)2 (7.8 mg, 0.035 minol), d icobalt octacarbonyl (59.0 mg, 0.173 minol), methyl-3-phenyl-2,3-d ihydrobenzofuran-7-carboxaminde (125 mg, 0.345 minol), d i((3S,5S,7S)-adamantan-1-yl)(butyl)phosphine (12 mg, 0.035 minol) and tert-butyl 4-(3-aminopropyl)piperazine-1-carboxylate (168 mg, 0.690 minol) then was filled with THF (2 mL). The resulting minxture was stirred under mincrowave irradiations at 110C for 1 h then was cooled to room temperature and treated with TFA (1.4 mL, excess). The resulting minxture was stirred at this temperature for 10 min, then was filtered over Celite (2.5 g pad) and concentrated in vacuo. The residue was co-evaporated with a 2NNH3 solution in MeOH (10 mL), and then was purified by MDAP (method high pH) to give (2S,3S)-2- (hydroxymethyl)-N7-methyl-3-phenyl-N5-(3-(piperazin- 1-yl)propyl)-2,3-dihydrobenzofuran-5,7- dicarboxaminde (15 mg, lO%).LCMS (method forminc): Retention time 0.39 min [M+H] = 453, 373608-48-1
The synthetic route of 373608-48-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen, John; DEMONT, Emmanuel, Hubert; HARRISON, Lee, Andrew; PRESTON, Alexander, G.; SEAL, Jonathan, Thomas; WALL, Ian, David; WATSON, Robert, J.; WOOLVEN, James, Michael; (214 pag.)WO2017/174620; (2017); A1;,
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