With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.393781-70-9,(R)-1-Boc-2-Ethylpiperazine,as a common compound, the synthetic route is as follows.,393781-70-9
The original compound 82a is4-chloro-N- (1-methyl-1H-pyrazol-4-yl) pyrimidin-2-amine (627 mg, 3.00 mmol)And N, N-dimethylformamide (20 mL)Into a single-mouth bottle,Then compound 90b is(R) -2-Ethylpiperazine-1-carboxylic acid tert-butyl ester(632mg, 3.0mmol)And cesium carbonate (1.95g, 6.0mmol)Into a single-mouth bottle,The reaction was carried out at 90 C for 16 hours.Add the reaction solution after washingEthyl acetate extraction (100mL * 3),Combined organic phases,After washing with water and saturated saline,Dry and concentrated,Purification by column (ethyl acetate / methanol = 20/1) gave compound 90c as a pale yellow solid, namely(R) -2-ethyl-4- (2-((1-methyl-1H-pyrazol-4-yl) amino) pyrimidine-4-yl) piperazine-1-carboxylic acid tert-butyl ester(740 mg, 55% yield).
The synthetic route of 393781-70-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Jiaxing Tekeluo Biological Technology Co., Ltd.; Xing Li; Li Guanqun; Wang Xiaolei; Cai Yuting; Jiang Xiang; Pan Xiang; Zhu Wenhao; Wang Yang; Wang Zengquan; (51 pag.)CN110862376; (2020); A;,
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