161357-89-7, 1-(Methylsulfonyl)piperazine hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: 0.20 mL of 2 N NaOH was added to a solution of 31 (46 mg, 0.10 mmol), prepared in a similar manner as described for 10c, in 2 mL of THF. The resulting medium was refluxed for 5 h. Additional 0.20 mL of 2 N NaOH was added to the reaction solution. Then the reaction was stirred for another 3 h under reflux. After concentration, the remaining residue was acidified to pH 2-3 by adding 1 N HCl and extracted with EA. The organic layer was dried over anhydrous Na2SO4 and concentrated under vacuum to give a crude acid (43 mg). The crude acid was dissolved in 2 mL of DMF and the solution was cooled in an ice bath. To the solution was successively added HATU (0.10 mmol), DIPEA (36 muL, 0.20 mmol) and dimethylamine hydrochloride (10 mg, 0.12 mmol). The resulting medium was stirred at room temperature for 1 h and quenched with 2 mL of saturated NaHCO3. The mixture was extracted with 50 mL of EA. The organic layer was washed with water (2 × 10 mL), brine, dried over anhydrous Na2SO4 and concentrated under vacuum. The crude product was purified by flash column chromatography (0-3% MeOH/EA gradient) to afford compound 10g in 48% yield., 161357-89-7
161357-89-7 1-(Methylsulfonyl)piperazine hydrochloride 16265612, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Zhang, Dengyou; Zhang, Xiaowei; Ai, Jing; Zhai, Yun; Liang, Zhongjie; Wang, Ying; Chen, Yi; Li, Chunpu; Zhao, Fei; Jiang, Hualiang; Geng, Meiyu; Luo, Cheng; Liu, Hong; Bioorganic and Medicinal Chemistry; vol. 21; 21; (2013); p. 6804 – 6820;,
Piperazine – Wikipedia
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