With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.,115619-01-7
EXAMPLE IB5-bromo-N2-[4-(4-ethylpiperazin-l-yl)phenyl]-N4-[2-(trifluoromethyl)-lH-benzimidazol-5-yl]pyrimidine-2,4-diamineA scintillation vial was charged with EXAMPLE IA (98 mg, 0.25 mmol), 4- (4- ethylpiperazin-l-yl)aniline (66.7 mg, 0.325 mmol), n-butanol (4 ml) and 4 N hydrogen chloride in dioxane (62.5 muL, 0.250 mmol). The mixture was stirred at 80 0C overnight. The reaction mixture was cooled and quenched with water (10 mL), adjusted to pH -135089667 1 with slow addition of cone. aq. NaOH. The mixture was extracted with ethyl acetate and the extract was concentrated. The crude product was purified with HPLC on a Cl 8 reverse-phase column using a gradient of water and acetonitrile with 0.1% TFA as a buffer. The title compound was obtained as the TFA salt as an off-white solid (100 mg, 51%). MS: (ESI(+)) m/e 561.2, 563.2 (M+H)+; 1H NMR (500 MHz, DMSO-d6) delta ppm 9.53 (bs, IH), 9.39 (s, 1 H), 8.99 (s, IH), 8.22 (s, IH), 7.94 (s, IH), 7.73 (d, IH), 7.57 (d, IH), 7.43 (d, 2H), 6.76 (d, 2H), 6.51 (s, IH), 3.66-3.53 (m, 4H), 3.21-3.09 (m, 4H), 2.87 (U H), 1.26 (q, 3H).
115619-01-7 4-(4-Ethylpiperazin-1-yl)phenylamine 936738, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; ABBOTT LABORATORIES; WANG, Gary, T.; MANTEI, Robert, A.; ERICKSON, Scott, A.; FIDANZE, Steve, D.; SHEPPARD, George, S.; WANG, Jieyi; BELL, Randy, L.; WO2010/138578; (2010); A1;,
Piperazine – Wikipedia
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