With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Step A: Preparation of (3R,5S)-tert-butyl 3,4,5-trimethylpiperazine-l- carboxylate: (3R,5S)-tert-Butyl 3,5-dimethylpiperazine-l-carboxylate (1.50 g, 7.00 mmol) was dissolved in 70 mL of methanol. To this was added 37%> aqueous formaldehyde (1.17 mL, 14.0 mmol) and formic acid (1.14 mL, 24.5 mmol). The reaction mixture was heated to 70 C for 24 hours, then concentrated under reduced pressure. The resulting oil was taken up in EtOAc, washed with 10%> aqueous potassium carbonate, dried over sodium sulfate and concentrated to give 1.17 g (73%>) of the title compound., 129779-30-2
As the paragraph descriping shows that 129779-30-2 is playing an increasingly important role.
Reference：
Patent; ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; DELISLE, Robert Kirk; HICKEN, Erik James; KENNEDY, April L.; MARESKA, David A.; MARMSATER, Fredrik P.; MUNSON, Mark C.; NEWHOUSE, Brad; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian; WO2012/82689; (2012); A1;,
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