4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of tert-butyl 4-hydroxypiperidine-1-carboxylate (4.4 g, 21.9 mmol) in 0CM (100 mL) was carefully added OMAP (5.3g, 43.Bmmol) and triphosgene (3.2g. 10.95 mmol) portionwise. After stirring at ft for 2h, 1-isopropylpiperazine (3.3g. 26 mmol) was added and the reaction mixture was stirred at ft for 5 h. The reaction was quenched with saturatedNH4CI (100 mL) solution and the mixture was extracted with 0CM (3×1 00 mL). The combined organic layers were washed with saturated NH4CI (2×100 mL) and brine (SOmL) sequentially, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford thetitle compound as a white solid (7.7g. 99%). [LCMS: Rt1.67min, mz 356.3 (M + H)1., 4318-42-7
4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; NOVARTIS AG; AUBERSON, Yves; BOCK, Mark Gary; BRAGA, Dario; CURZI, Marco; DODD, Stephanie Kay; GIAFFREDA, Stefano Luca; JIANG, Haiyang; KARPINSKI, Piotr; TROXLER, Thomas J.; WANG, Tielin; WANG, Xiaoyang; ZHANG, Xuechun; WO2014/13469; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics