With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-30-0,1-Boc-2-methyl-3-oxopiperazine,as a common compound, the synthetic route is as follows.
76003-30-0, To a heterogeneous mixture of Lawesson’s reagent (2.11 g, 5.06 mmol) in toluene (18 mL) was added the product of Example 1, step a (1.01 g, 4.73 mmol). The mixture was heated at 80 C for 1 h and then concentrated in vacuo. The residue was dissolved in DCM and filter loaded on Si02 column eluting with EtO Ac/Hex to afford the desired product as an orange solid (1.12 g, 100%).
The synthetic route of 76003-30-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; JANSSEN PHARMACEUTICA NV; ANDRES GIL, JOSE IGNACIO; LETAVIC, MICHAEL A; RECH, JASON C; RUDOLPH, DALE A; SOYODE-JOHNSON, AKINOLA; CHROVIAN, CHRISTA C; (158 pag.)JP2017/527588; (2017); A;,
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