163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The compound (R) -4- tert-butoxycarbonyl-2-methyl-piperazine (0.5g, 2.5mmol) and triethylamine (1.1mL,7.5mmol) was dissolved in dry Tetrahydrofuran (10mL), and at room temperature, to this solution was addeddropwise trimethylsilyl isocyanate (1.0mL, 7.5mmol), stirred at room temperature Stirred 1.5h, and ice water (10mL), tetrahydrofuran spin, the aqueous phase with ethyl acetate (30mL × 3). The organic phase was dried overanhydrous Na 2 SO 4 Dried to remove the solvent, the concentrated solution separated by columnchromatography (eluent: DCM / MeOH (v / v) = 40/1), to give a white solid 500mg: (R) -4–carbamoyl-3-methyl-piperazine-1-carboxylate, yield: 82%., 163765-44-4
As the paragraph descriping shows that 163765-44-4 is playing an increasingly important role.
Reference：
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
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