With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196811-66-2,tert-Butyl 4-carbamothioylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
6.4 g (26.09 mmol) tert-butyl-4-(aminocarbothioyl)piperazine 1-carboxylate and 3.8 mL CH3I in 80 mL dichloromethane were stirred for 4 days at room temperature. Evaporation of the mixture yielded the corresponding methyl compound as the hydroiodide which was reacted further without further purification., 196811-66-2
196811-66-2 tert-Butyl 4-carbamothioylpiperazine-1-carboxylate 12093220, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Amberg, Wilhelm; Netz, Astrid; Kling, Andreas; Ochse, Michael; Lange, Udo; Hutchins, Charles W.; Garcia-Ladona, Francisco Javier; Wernet, Wolfgang; Hahn, Alfred; US2010/41698; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics