With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
Adding 2, 6-lupetazin (11.4g, 100mmol, 1eq) and di-tert-butyl dicarbonate (21.8g, 100mmol, 1eq) into a 250mlflask; and then adding 100ml tetrahydrofuran, reacting under room temperature for 4 hours; and condensing up tetrahydrofuran(i.e., condensing tetrahydrofuran until used up), 21.4g orange-colored oily substance ZTH-1 is obtained, whereinthe yield is 100%., 21655-48-1
As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.
Reference：
Patent; Suzhou Maidixian Pharmaceutical Inc.; Zhang, Nan; Zhong, Rong; ZHANG, Nan; ZHONG, Rong; EP2589601; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics