163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
163765-44-4, The compound (R) -3- methyl-piperazine-1-carboxylate (250mg, 1.25mmol), cyclopropanecarboxylic acid(130mg, 1.50mmol), 1- Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (480mg, 2.50mmol)and N- hydroxy-7-aza-benzotriazole (254mg, 1.87 mmol) were dissolved in dichloromethane (10 mL), and theconditions under 0 C, to this solution was added dropwise N, N- diisopropylethylamine (0.65mL, 3.74mmol), stirred for 10H at room temperature, add water (10mL × 3) washing the organic phase was dried overanhydrous Na 2 SO 4, the solvent was removed, the concentrate was subjected to column Chromatography(eluent: Petroleumether / EtOAc (v / v) = 2/1), to give 310mg of colorless liquid: (R) -4- (cyclopropylcarbonyl)-3- Methyl-piperazine-1-carboxylate, yield: 93%.
163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics