With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
Benzyl piperazine-1-carboxylate (1.00 g, 4.54 mmol) and K2CO3 (1.255 g, 9.08 mmol) were dissolved in acetonitrile (12.87 ml) to form a suspension. 1-bromo-2-chloroethane (2.3 ml, 27.24 mmol) was added to the reaction mixture at r.t and the resulting mixture was stirred at this temperature for 96 hours.The reaction mixture was filtered, and the filtrate concentrated under reduced pressure.Purification by column chromatography (ISCO, silica gel column, eluting with 0?100percent EtOAc in hexanes) gave the title compound (0.64 g, yield: 50percent).1H NMR (300 MHz, CHLOROFORM-d) d ppm 7.28-7.43 (m, 5H) 5.15 (s, 2H) 3.48-3.65 (m, 6H) 2.76 (t, 2H) 2.42-2.57 (m, 4H).LCMS: (ESI) m/z 283 [M+H]+.
31166-44-6, The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ASTRAZENECA AB; US2012/35134; (2012); A1;,
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