With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.
Step 1: tert-butyl 4-(5-bromopyridin-2-yl)-3-oxopiperazine-1-carboxylate A mixture of 2,5-dibromopyridine (1.00 g; 4.22 mmol), tert-butyl 3-oxopiperazine-1-carboxylate (562 mg; 2.80 mmol) and Cs2CO3 (1.37 g; 4.20 mmol) in toluene (20 mL) was purged with nitrogen and added Pd2(dba)3 (129 mg; 0.14 mmol) and XantPhos (97 mg; 0.17 mmol). The reaction mixture was stirred at 100 C. overnight, cooled to room temperature, diluted with EtOAc (50 mL), filtered through Celite, washed with water (50 mL), brine (50 mL), dried over anhydrous Na2SO4, filtered, concentrated, and purified by a silica gel chromatography (petroleum ether/EtOAc=10/1, v/v) to afford 955 mg (96%) of the title compound as a yellow oil. LC-MS: m/z 355.8 [M+H]+., 76003-29-7
76003-29-7 1-Boc-3-Oxopiperazine 3157178, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; ITEOS THERAPEUTICS; Crosignani, Stefano; Cauwenberghs, Sandra; Driessens, Gregory; Deroose, Frederik; US2015/225367; (2015); A1;,
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