With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Step E: tert-butyl (3S)-4-(2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyll-3-(hydroxymethyl)piperazine-1-carboxylate; 2,6-Difluoro-3-( oxiran-2-yl)benzonitrile (1.50 g, 8.28mmol) and (S)-4-N-BOC-2-hydroxymethylpiperazine (2.40 g, 11.1 mmol) were suspended inethanol (15 mL) then heated in a microwave apparatus for 30 min at 150 C. The reactionmixture was cooled and evaporated dryness. The residue was purified by chromatographythrough a 120g Redi-sep column eluting with 5%MeOH/95% EtOAc to yield the title compoundLC-MS: M+ 1 = 398.·
314741-40-7, As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.
Reference：
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
Piperazine – Wikipedia
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