171504-98-6, Methyl 1,4-Bis(Boc)-2-piperazinecarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 1,4-di-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate (5.09 g, 14.7 mmol) in dry THF (49 mL) was added methylmagnesium bromide (3.0 M in THF and tol, 31.7 mL, 44.3 mmol) at 0 C. The reaction mixture was stirred at room temperature for 18 hours. After quenched with saturated aq. NH4Cl, the mixture was diluted with water and extracted with EtOAc twice. The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography on SiO2 (Hex:EtOAc=5:1 to 3:1 to 2:1) to afford di-tert-butyl 2-(2-hydroxypropan-2-yl)piperazine-1,4-dicarboxylate (2.47 g, 48%) as a colorless viscous oil. 1H-NMR (CDCl3, Varian, 400 MHz): delta 1.21 (3H, s), 1.31 (3H, s), 1.46 (18H, s), 3.01-3.38 (4H, m), 3.79-4.21 (4H, m)., 171504-98-6
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Reference：
Patent; HANDOK INC.; CMG Pharmaceutical Co., Ltd.; Kim, Moonsoo; Lee, Chaewoon; Lee, Gilnam; Yoon, Cheolhwan; Seo, Jeongbeob; Kim, Jay Hak; Lee, Minwoo; Jeong, Hankyul; Choi, Hyang; Jung, Myung Eun; Lee, Ki Nam; Kim, Hyun Jung; Kim, Hye Kyoung; Lee, Jae Il; Lee, MinWoo; Kim, Misoon; Choi, Soongyu; (124 pag.)US2016/168156; (2016); A1;,
Piperazine – Wikipedia
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